Tyco Electronics Corporation

Unitract Syringe Pty Ltd

Unl Holdings LLC

The Whitaker Corporation

Congruence Medical Solutions, LLC

Santen Pharmaceutical Co., Ltd.

US Conec Limited

Lou Castagna

Gautam N Shetty

Richard Dean Miller

Michael Lawrence Gurreri

Lance W Wetzel

Michael Aaron Kadar-Kallen

John Anthony Fulponi

Christian Perry Brandt

Tod Brenner

Donald Eugene Dellinger

Robert Nelson Fair, Jr

Aaron M Weir

Gautam Nithyanand Shetty

Daniel Edward Gillis

Darrell Randolph Childers

Terry P Bowen

David Donald Erdman

Hung Thai Nguyen

James David Kevern

Shelly Ann Buchter

Philip Clay Brandberg

William Lamar Herb

Mike Elbert Hughes

David William Cormany

Tod H Brenner

Timothy John Loftus

Gary Richardson

Nathaniel Ryan Young

Greg G Griffith

Christian P Brandt

Guatam N Shetty

Daniel E Gillis

According to some embodiments, a syringe may include a barrel; a delivery conduit; a plunger seal disposed within the barrel; and a plunger rod assembly affixed to an end of the barrel, the plunger rod assembly including a first plunger rod component comprising a first linear gear, a second plunger rod component disposed at least partially in the barrel and engaged with the plunger seal, wherein the second plunger rod component comprises a second linear gear, a first rotational gear having a plurality of gear teeth for engaging the first linear gear, and a second rotational gear having a second plurality of gear teeth for engaging the second linear gear, wherein the first rotational gear is coupled to the second rotational gear such that translation of the first plunger rod component causes translation of the second plunger rod component.

Accurate, precise microliter dosing syringe

A syringe includes a dosage setter operatively coupled to a plunger rod and comprising a rotatable body that comprises a set of one or more stops for engaging the set of one or more protrusions of the plunger rod depending on at least a rotational position of the set of one or more stops relative to the set of one or more protrusions, wherein a first rotational adjustment associated with the dosage setter is configured to set a first dosage increment by adjusting a relative axial position between the rotatable body and the plunger rod, and a second rotational adjustment associated with the dosage setting assembly is configured to set a second dosage increment that is larger than the first dosage increment by adjusting a relative rotational alignment between the set of one or more stops and the set of one or more protrusions.

Variable dosing syringe

A mixing syringe including a valve mechanism is configured and configurable to enable one or more substances to be prefilled into the syringe. The valve mechanism may be an aspect of a distal seal assembly. Actuation of the valve mechanism permits opening of a fluid passage for mixing of the one or more substances, and a resulting mixed substance can be delivered by the syringe, for example, for administration of a pharmaceutical to a subject.

Syringes for prefilled and fill-at-use mixing and drug delivery

A barrel adapter mountable to a syringe barrel includes a barrel tip, a needle assembly, a stylet assembly slidably disposed within a needle lumen of the needle assembly, and a plug within the lumen of the needle. An implant delivery syringe includes a barrel, a plunger assembly, and the barrel adapter. The syringe may include a needle retraction mechanism having a biasing member and an actuable locking arrangement. When the actuable locking arrangement is actuated, the biasing member causes the needle to axially translate over the stylet during retraction to dislodge the plug and cause delivery of an implant to a target location. The plug may be a biodegradable polymer plug such as a water-soluble polymer, PLGA, and/or CARP. The stylet may be retracted following delivery. Methods of assembling implant delivery syringes with drug implants are also provided.

Devices for targeted delivery of therapeutic implants

An automatic accurate dose syringe includes a barrel, a plunger seal, a barrel adapter assembly having a barrel tip and a needle, and a dose control mechanism having a plunger having a coarse pitch screw on its exterior surface, a housing having a corresponding coarse pitch guide along the interior surface of the housing, a screw having a fine pitch screw which interfaces with a fine pitch nut of an adapter, wherein the plunger has an internal annular space within which screw at least partially resides. The syringe further includes a locking mechanism, an activation button, and a biasing member such as a compression and/or a torsional spring. The components are configured such that actuation of the activation button by the user manipulates the locking mechanism to permit the biasing member to move from an initial energized state to a lower energy state, thereby automating drug delivery from the syringe.

Automatic self-dispensing accurate dose drug delivery syringes

A dose control mechanism for a syringe includes an engaging screw thread arrangement between an exterior surface of a plunger and a longitudinally extending channel of a housing. The engaging screw thread arrangement includes at least one thread segment and a pitch guide including a variable pitch thread. At least a portion of the longitudinally extending channel of the housing including one of the pitch guide and the at least one thread segment, and the plunger includes the other of the pitch guide and the at least one thread segment. The plunger resides at least partially within the housing with the at least one thread segment engaged with the pitch guide. An accurate dose drug delivery syringe includes such a dose control mechanism, a barrel, a plunger seal, and a barrel adapter assembly having a barrel tip and a needle. The syringe may be a fill-at-time-of-use syringe, a pre-filled syringe, or a safety syringe having integrated needle retraction or needle sheathing safety features, or a combination thereof. Methods of assembly, manufacturing, and operation are similarly disclosed.

Accurate dose control mechanisms and drug delivery syringes

Mixing syringes including a valve mechanism are configured and configurable to enable one or more substances to be prefilled into the syringe. The valve mechanism may be an aspect of a distal seal assembly. Actuation of the valve mechanism permits opening of a fluid passage for the mixing of one or more substances, and the resulting mixed substance can be delivered by the syringe, for example, for administration of a pharmaceutical to a subject.

Mixing syringes including a valve mechanism are configured and configurable to enable one or more substances to be prefilled into the syringe. The valve mechanism may be an aspect of a distal seal assembly. Actuation of the valve mechanism permits opening of a fluid passage for the mixing of one or more substances, and the resulting mixed substance can be delivered by the syringe, for example, for administration of a pharmaceutical to a subject. The repetitive mixing of substances contained in a distal and proximal chamber is also provided, where the plunger rod is configured to releasably engage a locking mechanism to actuate the valve, and can axially displace the distal seal assembly while the fluid passage is open.

Syringes for repetitive mixing and delivery of injectables

Sequential delivery syringes including a valve mechanism are configured and configurable to enable one or more substances to be prefilled into the syringe. The valve mechanism may be an aspect of a distal seal assembly. Actuation of the valve mechanism permits opening of a fluid passage for the mixing of one or more substances, and the resulting mixed substance can be delivered by the syringe, for example, for administration of a pharmaceutical to a subject. The sequential delivery of substances contained in a distal and proximal chamber is also provided, where a second substance from the distal chamber is delivered followed by the delivery of a first substance from the distal chamber after the first substance from the proximal chamber is transferred into the distal chamber involving the actuation of the valve mechanism.

Syringes for sequential delivery of injectables

A dose control mechanism for a syringe includes a plunger having a coarse pitch screw on its exterior surface, a housing having a corresponding coarse pitch guide along the interior surface of the housing, a screw having a fine pitch screw which interfaces with a fine pitch nut of an adapter, wherein the plunger has an internal annular space within which screw at least partially resides. An accurate dose drug delivery syringe includes such a dose control mechanism, a barrel, a plunger seal, and a barrel adapter assembly having a barrel tip and a needle. The syringe may be a fill-at-time-of-use syringe, a pre-filled syringe, or a safety syringe having integrated needle retraction or needle sheathing safety features, or a combination thereof. Methods of assembly, manufacturing, and operation are similarly disclosed.

An optical interposer comprising: (a) a crystalline substrate having a top planar surface and a crystalline plane angle; (b) a groove defined in the top planar surface and extending from an edge of the substrate to a terminal end, the groove having side walls and a first facet at the terminal end, the facet having a first angle relative to the top planar surface, the first angle being about the crystalline plane angle, the first angle having a delta from 45&#xb0;; (c) a reflective coating on the first facet; and (d) an optical conduit having an optical axis and an end face optically coupled with the first facet, the end face having a second angle with respect to the optical axis such that the angle of refraction at the end face compensates for the delta such that the end face and the first facet cooperate to bend light about 90&#xb0;.

Optical interposer with ninety degree light bending

An interposer comprising a plurality of optical conduits, each having an optical axis, a substrate defining a plurality of grooves having a terminal end, each optical conduit being disposed in a single groove, and a common angled surface traversing two or more of the grooves at the terminal end, at least a portion of the angled surface proximate the optical axes of the optical conduits in the two or more grooves is reflective, and one or more optical components disposed above the angled surface, the optical components and the optical conduits being optically coupled by the angled surface.

Optical interposer with common angled surface

An implant delivery syringe includes a barrel, a plunger assembly, and a barrel adapter. A barrel adapter mountable to a syringe barrel includes a barrel tip, needle retraction mechanism, needle assembly and stylet slidably disposed within the needle lumen. The needle retraction mechanism includes a biasing member, actuable locking arrangement and locking mechanism. When the actuable locking arrangement is actuated, the biasing member causes the needle to axially translate over the stylet during retraction to cause delivery of an implant to a target location. The stylet may be retracted following delivery. Methods of assembling, manufacturing, and using are also provided.

An optical interposer for optically coupling light between an OED supported on a substrate and an optical fiber, the interposer comprising: (a) an interposer of an optically-clear moldable material comprising at least the following features: (b) a port for receiving a ferrule containing at least one optical fiber, the port comprising an interface surface positioned to optically couple with an end face of the optical fiber; (c) an active lens adapted to optically couple with an OED, the active lens and the interface surface optically coupled along an optical path in the interposer; (d) a protrusion extending backward from the port, the protrusion defining a first register surface, the first register surface being a certain distance from the optical path such that, when a second register surface of a ferrule containing the optical fiber contacts the first register surface, the ferrule is aligned with the port such that the port can receive a front portion of the ferrule if the ferrule is pushed forward.

Interposer with alignment features

A multi-fiber ferrule and optical fibers therein make easier contact with other multi-fiber ferrules and connectors with a small fiber tip radius and a modulus of elasticity. A method for qualifying multi-fiber ferrules (and connectors) is also disclosed.

Growing community of inventors

Middletown, PA, United States of America

Lou Castagna