Abbott Cardiovascular Systems, Inc.

Advanced Cardiovascular Systems, Inc.

Alza Corporation

Other

Raychem Limited

Durect Corporation

Lothar W Kleiner

Stephen D Pacetti

Syed F A Hossainy

Jessica R DesNoyer

Syed Faiyaz Ahmed Hossainy

Thierry Glauser

Yiwen Tang

Mikael Trollsas

Yunbing Wang

James Oberhauser

Fuh-Wei Tang

Manish Gada

Ni Ding

Yung-Ming Chen

Michael H Ngo

Guohua Chen

Paul R Houston

Syed F Hossainy

David K Wrolstad

O Mikael Trollsas

John Joseph Stankus

Vincent J Gueriguian

Gordon S Stewart

Connie S Kwok

Bin Huang

J Richard Gyory

Jason Van Sciver

Ronald P Haak

Felix A Landrau

Benjamyn Serna

Xiao Ma

Wouter Erik Roorda

Robert M Gale

Jeremy C Wright

Florencia Lim

Santosh V Prabhu

Sean A McNiven

Keith E Dionne

Irina Astafieva

Bethany Steichen

Gina Zhang

Jessica Reneé DesNoyer

Shaw Ling Hsu

Bozena Zofia Maslanka

Wendy A Young

Harold F Sanders

Vidya J Nayak

Mary Beth Kossuth

Martin Matthiesen

John J Spaltro

Jessica Renee DesNoyer

Syed Faiyaz Shmed Hossainy

Randall G Berggren

Robert M Myers

Qing Lin

Zhongli Ding

Nam D Pham

David T Priebe

Eli J Goldman

Andrew F McNiven

Gilbert T Tong

Linda M Hearney

Erik R Scott

Stephanus Pudjijanto

Subramanian S Venkatraman

Jessica Reneé´ DesNoyer

Robert M Meyers

Teresa Kameda

Roy Bannister

Brandon J Yoe

Stephen Dirk Pacetti

Michael Huy Ngo

Mikael O Trollsas

Syed FA Hossainy

James P Oberhauser

Jessica Renee Desnoyer

Jessica Desnoyer

Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.

Controlling moisture in and plasticization of bioresorbable polymer for melt processing

The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.

Absorbable coating for implantable device

A stent made from an ultra high molecular weight bioabsorbable polymer is disclosed herein. The bioabsorbable polymer can have a Mw greater than 1 million g/mole or greater than 2 million g/mole. Methods of making the ultra high molecular weight polymer stent without degrading the molecular weight are further disclosed.

Stent made from an ultra high molecular weight bioabsorbable polymer with high fatigue and fracture resistance

The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix. The methods relate to the application of pressure, and optionally, in combination with heat, to a polymeric coating.

Methods of treatment of polymeric coatings for control of agent release rates

The present invention provides a semi-crystalline polymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.

Bioabsorbable semi-crystalline polymer for controlling release of drug from a coating

A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.

Polyesteramide platform for site specific drug delivery

A bioabsorbable scaffold composed of a multilayer structure of alternating layers of different polymers is disclosed. The multilayer structure can have 20 to 1000 layers and the individual thickness of the layers can be 0.2 to 5 microns. A method of making the scaffold including a layer multiplying extrusion process is disclosed.

Multilayer bioabsorbable scaffolds and methods of fabricating

The present invention provides an implantable device having a biosoluble coating comprising a polyelectrolyte and a counterion and the methods of making and using the same.

Soluble implantable device comprising polyelectrolyte with hydrophobic counterions

Provided herein is a prohealing piezoelectric coating and the method of making and using the same.

Prohealing piezoelectric coatings

Methods are disclosed for chemically stabilizing a polymer stent after sterilization. The stent is exposed to a temperature above ambient for a period of time after radiation sterilization. The exposure reduces the concentration of free radicals generated by the radiation.

Post electron beam stabilization of polymeric medical devices

Methods for fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube and fabricating a stent from the expanded tube are disclosed. The polymer tube is disposed within a mold and may be heated with radiation. The heated tube radially expands within the mold.

Tube expansion processes for semicrystalline polymers to maximize fracture toughness

Methods to expand polymer tubing with desirable or optimum morphology and mechanical properties for stem manufacture and fabrication of a stent therefrom are disclosed.

Controlling crystalline morphology of a bioabsorbable stent

Methods of fabricating a polymeric implantable device, such as a stent, with improved fracture toughness through annealing a polymer construct below the glass transition temperature of the polymer of the construct prior to a deformation step are disclosed herein. The deformation of the construct induces crystallization in the polymer construct through strain-induced crystallization. The annealing of the polymer construct accelerates the crystallization induced during the deformation and results in an increase in crystallite density with smaller crystallites as compared to deformation of a tube that has not been annealed. A stent scaffolding is then made from the deformed tube.

Medical device fabrication process including strain induced crystallization with enhanced crystallization

Growing community of inventors

Los Altos, CA, United States of America

Lothar W Kleiner