Jenapharm Gmbh

Lothar Sobeck

Walter Elger

Michael Oettel

Gerd Schubert

Anatoli Kurischko

G Unther Kaufmann

Gunther Kaufmann

This invention relates to new 11-benzaldoxime-estra-diene derivatives of the general formula I ##STR1## and their pharmaceutically acceptable salts, a method for their production, and pharmaceuticals containing such compounds. The compounds described show strong antigestagenic effects combined with reduced glucocorticoid activity.

11-benzaldoxime-estra-diene derivatives, methods for their production

This invention relates to new 11-benzaldoxime-estra-diene derivatives of the general formula I ##STR1## wherein Z is --CO--CH.sub.3, --CO--O--C.sub.2 H.sub.5, --CO--NH-phenyl, --CO--NH--C.sub.2 H.sub.5, --CO--C.sub.2 H.sub.5, --CH.sub.3, or --CO-phenyl and their pharmaceutically acceptable salts, a method for their production, and pharmaceuticals containing such compounds. The compounds of the general formula I are produced by esterifying or etherizing a compound of the general formula II ##STR2## The compounds described show strong antigestagenic effects combined with reduced glucocorticoid activity.

11-benzaldoxime-17.beta.-methoxy-17.alpha.-methoxymethyl-estrasdiene

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Jena, Germany

Lothar Sobeck