Hoffmann-la Roche Inc.

Boehringer Mannheim Gmbh

Roche Diagnostics Gmbh

Other

Prof. Dr. Wolf-georg Forssmann

Lothar Kling

Wolfgang Von Der Saal

Walter-Gunar Friebe

Ulrike Reiff

Thomas Von Hirschheydt

Angelika Esswein

Alfred Mertens

Birgit Bossenmaier

Bernd Muller-Beckmann

Edgar Voss

Thomas Friess

Frederick Arthur Brookfield

Ulrike Leser

Wolf-Georg Forssmann

Kurt Lang

Hans-Willi Krell

Michael Edward Prime

Konrad Honold

Georg Tiefenthaler

Matthias Rueth

Jens-Peter Holck

Markus Meyer

Manfred Schwaiger

Irene Kolm

Hans-Georg Opitz

Jonathan Gridley

Eike Hoffmann

Reinhard Koenig

Rolf Juchem

Hossein Mostafavi

Silvia Konetschny-Rapp

Tim Boelke

Objects of the present invention are the compounds of formula I, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer. 

Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents

Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer. 

Aryl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents

The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of such compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.

Pyridylsulfonamide derivatives

The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing such compounds and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.

Phenylpyridine derivatives

The present invention provides the compounds of formula I their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

Oxidized thioether derivatives

Objects of the present invention are the compounds of formula (I) formula (I),their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

Thioether derivatives

The invention is directed to compounds of formula (I) wherein Ralkyl, alkenyl or alkynyl having from 6 to 24 carbon atoms; n=0-12; X=oxygen or NH; and the physiologically safe salts, esters, optically active forms, racemates and derivatives thereof which can be metabolized in vivo to yield compounds of general formula (I), methods of preparing same, and drugs containing said compounds, for treating bone metabolic disorders.

Osteoblast-specific mitogens and drugs containing such compounds

A peptide referred to as cadherin-derived growth factor (CDGF) the sequence of which corresponds to a partial sequence of a pre-pro-cadherin, said pre-pro-cadherin comprising the domains signal sequence, pro sequence cadherin repeats, transmembrane region and intracellular domain, characterized in that the sequence of said peptide comprises the pro sequence, that at least one of the other domains of the pre-pro-cadherin is lacking, and that said peptide has cell-proliferative, cell-protective and/or cell-differential properties.

Cadherin derived growth factor and its use

Amino alcohol derivatives, method of producing said derivatives and medicaments containing them

Arginine mimetic peptides according to Formula I of this application have a stimulating effect on bone formation and are useful for the treatment of bone metabolic disorders.

Peptides containing an arginine mimetic for the treatment of bone metabolic disorders, their production, and drugs containing these compounds

Osteoblast-specific mitogens and drugs containing such compounds can be used for treating metabolic bone diseases. These compounds include lysophosphatidylic acid derivatives selected from the group consisting of compounds of formula:

Use of plasminogen activators to stimulate local bone growth

Use of torasemide for the treatment of brain edemas and orally and parenterally administerable torasemide.

Use of torasemide for the treatment of brain oedemas

Gem 3 dialkyl or spiro 4 aryl or heteroaryl 5 heterocyclic 3 H indoles and their pharmaceutically acceptable salts are prepared. They are useful for reducing blood pressure producing a positive inotropic action influencing thrombocyte aggregation and improving microcirculation. Hydrazinophenyl heterocyclic intermeidates are also disclosed.

2 heteroaryl 3,3 dialkyl-5-(3 oxo-2,3,4,5 tetrahydro-6

The present invention concerns new 5-alkylbenzimidazoles of the formula: ##STR1## wherein R.sub.1 is a phenyl ring of the formula: ##STR2## or R.sub.1 is naphthyl, heterocycle or a bicyclic heterocycle and R.sub.1 -R.sub.7 are described in claim 1. These compounds are useful for prophylaxis or treatment of heart and circulatory disease especially to increase contractility of the heart, lower blood pressure and/or influence the thrombocyte function and improve the microcirculation.

Growing community of inventors

Mannheim, Germany

Lothar Kling