Apotex Pharmachem Inc.

Lotfi Derdour

Allan W Rey

Stephen E Horne

Probal Kanti Datta

Martin Ehlert

K S Keshava Murthy

Carlos Zetina-Rocha

Ks Keshava Murthy

Keshava K S Murthy

Matthew A Buck

Stephen E Home

A process for the preparation of an acid addition salt of an organic base comprising exposing the organic base in solid form to a gaseous acid, with the proviso that ziprasidone, its acid addition salts and intermediates thereof are excluded.

Preparation of acid addition salts of amine bases by solid phase&#x2014;gas phase reactions

The present invention relates to a new and useful amorphous form of ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride) and preparations thereof.

Amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride) and processes to produce the same

A process for the preparation of an acid addition salt of ziprasidone base and intermediates thereof comprising exposing the ziprasidone base in solid form to a gaseous acid in a substantially dry environment.

Preparation of acid addition salts of ziprasidone and intermediates thereof by solid phase-gas phase reactions

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Brantford, Canada

Lotfi Derdour