Verdia Inc.

Pioneer Hi-bred International, Inc.

Maxygen, Inc.

Codexis, Inc.

E.i. Dupont De Nemours and Company

E. I. Du Pont De Nemours

California Institute of Technology

Novozymes A/s

Calysta, Inc.

Pioneer Hi-bred Int'l Inc.

Codexis Mayflower Holdings, LLC

Other

Novozymas Als

Codexis Mayflower Holding, LLC

Lorraine Joan Giver

Jeremy S Minshull

Phillip A Patten

Nicholas B Duck

Linda A Castle

Yong Hong Chen

Dan Siehl

Rebecca Lynne Gorton

Cristina Ivy

Billy Fred McCutchen

Roger Kemble

Willem P C Stemmer

Matthew B Tobin

Claes Gustafsson

Mark D Welch

Sergey A Selifonov

Stephen B Del Cardayre

Torben Vedel Borchert

Jon Edward Ness

Joel R Cherry

Frances H Arnold

Lisa Marie Newman

Stephane J Jenne

Joseph A Affholter

John H Grate

Christina Ivy

Gjalt W Huisman

Emily Mundorff

Joshua A Silverman

Behnaz Behrouzian

James Joseph LaLonde

Zhixin Shao

Drew D Regitsky

Huimin H Zhao

Jian Ding

Brian S Carr

Robin A Emig

Steven Henry Bass

Andreas Crameri

Renee M Saville

Kurt William Vogel

Sun Ai Raillard

Stanley Goldman

Pascal Longchamp

Jeremy Minshull

Jun Zhu

Vesna Mitchell

Willem P Stemmer

Benjamin Mijts

Richard John Fox

S Christopher Davis

Stephan Jenne

Jurgen Carsten Franz Knotzel

Luan Thanh Nguyen

Frank Mikkelsen

Sol M Resnick

Stefan Minning

Lynne Gilson

Niels Henrik Sorensen

Douglas A Hattendorf

Simon Christopher Davis

Jeffrey Colbeck

Trish Choudhary

Eric G Luning

Howard Lam Ho Fong

Tina Sejersg&aring;rd Fan&oslash;

Brandon D Doss

Bumshik Robert Pak

Claus Gustafsson

Jana Mueller

Billy Fred Mccutchen

Daniel Held

The present disclosure relates to recombinant microorganisms engineered for enhance production of a desired amino acid, as well as related biomass, and compositions which are useful, inter alia, as animal feed ingredients. The present invention also provides related methods.

Microorganisms for the enhanced production of amino acids and related methods

The present disclosure relates to recombinant microorganisms engineered for enhanced production of a desired carbohydrate, as well as related biomass, and compositions which are useful, inter alia, as animal feed ingredients. The present disclosure also provides related methods.

Carbohydrate-enriched recombinant microorganisms

The present disclosure provides compositions and methods for using recombinant C1 metabolizing microorganisms capable of metabolizing sulfur containing compounds and other contaminants to biologically convert sour or acidic natural gas into high-value molecules, and to allow recovery of stranded oil.

Compositions and methods for recovery of stranded gas and oil

The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.

Polynucleotides encoding ketoreductases for producing stereoisomerically pure statins and synthetic intermediates therefor

The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.

Combined automated parallel synthesis of polynucleotide variants

Engineered ketoreductases and methods for producing stereoisomerically pure statins

Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.

Glyphosate-N-acetyltransferase (GAT) genes

Proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are polynucleotides capable of encoding these proteins, compositions that include one or more of these proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these compounds, diversification methods involving the compounds, and methods of using the compounds. Some of the methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.

Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.

Integrated systems and methods for diversity generation and screening

In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided. One disclosed method involves identifying and producing a polypeptide. The method may involve (a) receiving data identifying sequences of two or more parental polypeptides or parental nucleic acids that encode the polypeptides; (b) selecting one or more cross-over sites on the sequences thereby defining one or more recombinant polypeptides or recombinant nucleic acids; (c) selecting at least one of the recombinant polypeptides or recombinant nucleic acids; (d) recombining one or more oligonucleotides, at least one of which has a sequence matching some or all of that of the recombinant polypeptides or recombinant nucleic acids selected in (c); (e) selecting at least some of the recombined oligonucleotides produced in (d); and (f) producing a polypeptide encoded by the selected nucleic acid.

Methods for identifying and producing polypeptides

Growing community of inventors

Sunnyvale, CA, United States of America

Lorraine Joan Giver