Amphivena Therapeutics, Inc.

Xencor, Inc.

Anji Bruno, LLC

Genentech, Inc.

Biogen, Incorporated

Lori Kunkel

Luke Evnin

Jeanmarie Guenot

Melvyn Little

Uwe Reusch

Stefan Knackmuss

Ivica Fucek

Kristina Ellwanger

Erich Rajkovic

Judith A Fox

Michael Weichel

Vera Molkenthin

Eugene Zhukovsky

Claudia Wall

John R Desjarlais

Gregory Alan Lazar

Sher Bahadur Karki

Seung Yup Chu

Bao-lu Chen

Philip W Hammond

David F Carmichael

Antonio J Grillo-Lopez

John G Curd

Jeanmarie Dean Guenot

Bao-Lu Chen

Described herein are binding proteins that specifically bind to human CD33, and in particular to bispecific binding proteins that specifically bind to human CD33 and human CD3. Also described herein are bispecific tandem diabodies that bind to CD33 and CD33, and their uses for immunotherapy of CD33cancers, diseases and conditions such as acute myeloid leukemia (AML).

Methods of using bispecific CD33 and CD3 binding proteins

Described herein are binding proteins that specifically bind to human CD33, and in particular to bispecific binding proteins that specifically bind to human CD33 and human CD3. Also described herein are bispecific tandem diabodies that bind to CD33 and CD33, and their uses for immunotherapy of CD33+ cancers, diseases and conditions such as acute myeloid leukemia (AML).

Bispecific CD33 and CD3 binding proteins

An antibody that targets CD30, wherein the antibody comprises at least one modification relative to a parent antibody and the antibody binds with altered affinity to an Fc&#x3b3;R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the anti-CD30 antibody.

Optimized anti-CD30 antibodies

An antibody that targets CD30, wherein the antibody comprises at least one modification relative to a parent antibody and the antibody binds with altered affinity to an FcgR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the anti-CD30 antibody.

Growing community of inventors

San Francisco, CA, United States of America

Lori Kunkel