Roche Madison Inc.

Mirus Bio Corporation

Lori Higgs

Jon Asher Wolff

Sean D Monahan

Darren H Wakefield

James E Hagstrom

David B Rozema

So Wong

Alexander V Sokoloff

James Ludtke

Magdolna G Sebestyén

David L Lewis

Vladimir S Trubetskoy

Hans Herweijer

Aaron G Loomis

The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.

Endosomolytic poly(acrylate) polymers

Endosomolytic poly(vinyl ether) polymers

The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in vivo delivery. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.

Membrane active heteropolymers

Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.

Compositions and processes using siRNA, amphipathic compounds and polycations

We describe compounds that bind to and are internalized by hepatocytes. Association of these compounds to other molecules or complexes can be used to target the molecules or complexes to hepatocytes in vivo or in vitro.

Compounds for targeting hepatocytes

Compounds for targeting hepatocytes in vivo

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Madison, WI, United States of America

Lori Higgs