Schering Corporation

Merck Sharp + Dohme Corp.

Loretta A Bober

Chuan-Chu Chou

Lee Sullivan

Jay S Fine

Michael J Grace

Arthur G Taveras

Younong Yu

Daniel M Solomon

Margaret H Sherlock

Purakkattle J Biju

Jianhua Chao

William Kreutner

Daniel Lundell

James P Jakway

Martin A Schwarz

Motasim Billah

Lee M Sullivan

James Jakway

The present invention provides polypeptides including MCP1 fused, optionally, by a linker, to an immunoglobulin. Methods for using the polypeptides to treat medical disorders are also covered.

Method for treating atherosclerosis by administering human MCP1 fusions

Methods for treating rheumatoid arthritis and multiple sclerosis using MCP1 fusions

Methods of treating chemokine-mediated diseases are disclosed. The methods comprise the administration of CXC-Chemokine receptor antagonists of the formula or pharmaceutically acceptable salts or solvates thereof, in combination with other classes of pharmaceutical compounds. The chemokine-mediated diseases include acute and chronic inflammatory disorders, psoriasis, cystic fibrosis, asthma and cancer. Also disclosed are novel compounds of formula (I).

Treatment of chemokine mediated diseases

MCP1 fusions

Compounds of formula ##STR1## or pharmaceutically acceptable salts thereof, wherein E, Q, T, U, V, L, Z, X, W, M, Y and Y' are as set forth herein, are described. These compounds are useful as agents in the treatment of allergy, inflammation, autoimmune diseases, B-cell lymphomas, tumors, and the after effects of bone marrow transplantation.

Naphthyridines which affect IL-4 and G-CSF

Disclosed are methods of enhancing the reparative phase of wound healing and repair in a mammal by administering to the wound site during the reparative phase an effective amount of IL-4. Also disclosed are methods of enhancing the healing and repair of infected wounds, wounds of diabetic mammals, and wounds of immunocompromised mammals by administering a therapeutically effective amount of IL-4 to the wound.

Method for enhancing wound healing/repair with IL-4

Growing community of inventors

Linden, NJ, United States of America

Loretta A Bober