Ge Healthcare As

Ge Healthcare Limited

Polydisplay Asa

Sinvent As

Lorenzo Williams

Bengt Langstrom

Anthony Eamon Storey

Farhad Karimi

Steven Michael Fairway

Alexander Mark Gibson

Robert James Nairne

Clare Louise Jones

Denis Raymond Christophe Bouvet

Nicolas Lasbistes

Ruth Schmid

Anne Dalager Dyrli

Kjetil A Netland

Maxim Miltrokhin

Jan K Nielsen

Cecilie Kristiansen

Fiona J Farrand

Kjetil H Holm

Maxim V Mitrokhine

Nicholas Lasbistes

Jarle Andre Haugan

Gunnar Keilen

The invention relates to a process for preparation of a compound of formula (I): Ris selected from Calkyl, Calkenyl, and Calkynyl;which comprises:(i) reaction with fluoride, suitably [F]fluoride, of a corresponding compound of formula (II): wherein Ris selected from hydrogen, Calkyl, Chaloalkyl, Caryl, Carylalkyl, &#x2014;(CHCHO)&#x2014;CHwherein q is an integer of from 1 to 10;Ris as defined for the compound of formula (I); andRis a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.

Fluorination process

The invention relates to a process for preparation of a compound of formula (I): Ris selected from Calkyl, Calkenyl, and Calkynyl; which comprises: (i) reaction with fluoride, suitably [F]fluoride, of a corresponding compound of formula (II): wherein Ris selected from hydrogen, Calkyl, Chaloalkyl, Caryl, Carylalkyl, &#x2014;(CHCHO)&#x2014;CHwherein q is an integer of from 1 to 10; Ris as defined for the compound of formula (I); and Ris a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed. 

Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents

The present invention addresses a novel method of preparing radiofluorinated peptide-based compounds and introducing those compounds into an automated radiosynthesis apparatus with the aid of microwave activation. The present invention further relates to obtaining radiopharmaceutical kits utilizing microwave activation technology for the preparation of obtaining peptide based compounds as well as a method for the use of preparing a peptide based compound.

Synthesis of radiofluorinated peptide using microwave activation technology

The present invention encompasses a method of preparing a radiofluorinated compound by adding a photolabile protecting group, R, to an aminoxy group of a peptide based compound wherein the peptide based compound reacts with a light of a specified wavelength in an automated radiosynthesis apparatus to form a radiofluorinated compound. The present invention further relates to a photolabile peptide based compound.

Synthesis of a radiofluorinated peptide using photolabile protecting groups

An ionic dopant comprising a sulfur or a phosphorus containing anion with a randon cation, for use in a smectic A liquid crystal composition. The cation preferably comprises a quaternary ammonium cation.

Liquid crystal dopants

This invention relates to a method for encapsulation of liquid crystals to form spherical particles with a narrow size distribution. More specific, this invention relates to a method for encapsulation of liquid crystals that are suitable to be employed in liquid crystal displays, including displays intended to be used in large boards outdoors.

Method for encapsulation of liquid crystals with a narrow capsule size range

A method for sequentially performing a synthesis, separation and screening of chemical entities, especially a combinatorial library, is described. The method utilises a bulk of a stationary phase (e.g. silica gel, aluminium oxide, cellulose, etc. for example arranged on a backing) for the performance of the synthesis, separation and screening. The technique described enables a rapid route from synthesis to the testing of chemical compounds. Screening can be performed without need for reaction work-up. Preferred screening methods are those used to determine the biological activity of the compounds.

Method for synthesis, separation and screening of a plurality of compounds in the same bulk of a stationary phase

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Oslo, Norway

Lorenzo Williams