Bracco Imaging S.p.a.

Università Degli Studi Del Piemonte Orientale “a. Avogadro”

Sol S.p.a.

Universita Degli Studi Del Piemonte Orientale "amedeo Avogadro"

Lorenzo Tei

Zsolt Baranyai

Mauro Botta

Mariangela Boccalon

Jonathan Martinelli

Fabio Carniato

Leonardo Marchese

Giorgio Gatti

Maurizio Cossi

Mina Errahali

Rigidified pentadentate chelating agents of Formulae (I) and (II), which are useful for the [AlF]labelling of biomolecules are provided. The rigidified pentadentate chelating agents are used to form coordination complexes with [AlF], which are particularly advantageous for use as tracers in molecular imaging techniques.

Rigidified pentadentate chelating agents useful for the [AlF]labelling of biomolecules

The invention relates to the novel compounds of formula (I) as well as ions, stereoisomers, tautomers, hydrates, solvates, pharmaceutically acceptable salts thereof, or mixtures of the same. The compounds of formula (I) are ligands that are able to chelate Fe(III) ions, thereby generating Fe(III) complexes, which are particularly suitable in diagnostic imaging, for example as contrast agents for magnetic resonance imaging (MRI), due to their high relaxivity, thermodynamic stability, kinetic inertness and redox stability.

1,4-bis-(2-hydroxy-benzyl)-1,4,7-triazacyclononane derivatives and similar compounds as ligands in iron(III) complexes for use as MRI contrast agents

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Turin, Italy

Lorenzo Tei