Farmitalia Carlo Erba

Farmitalia Carlo Erba S.r.l.

Farmitalia Societa Farmaceutica Italia

Lorenzo Pegrassi

Alessandro Rossi

Sergio Mantegani

Luigi Bernardi

Aldemio Temperilli

Enzo Brambilla

Metilde Buonamici

Gabriella Traquandi

Ettore Lazzari

Giuseppe Mazzini

Severina Coda

Giselbert Karl Suchowsky, Deceased

Maria L Malnati

Use of ergoline derivatives in treating emesis

Compounds of the formula I ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group, either R.sub.2 and R.sub.3 represent hydrogen atoms or together represent a chemical bond, R.sub.4 represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, R.sub.5 represents a C.sub.1 -C.sub.4 alkyl group or an allyl group and R.sub.6 represents a hydrogen or halogen atom, and pharmaceutically acceptable salts thereof, are disclosed as being useful for the treatment of extrapyramidal syndromes such as Parkinson's disease.

Antiparkinson ergoline derivatives

Ergoline derivatives of the formula I ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group; R.sub.2 represents a hydrogen atom or a methoxy group;

Ergolinyl heterocycles for the treatment of Parkinson's disease and

The invention relates to ergoline derivatives having the general formula (I): ##STR1## where R=H, CH.sub.3 ; R.sub.1 =H, halogen, CH.sub.3, phenylthio, C.sub.1 -C.sub.4 alkylthio; R.sub.2 =H, CH.sub.3 O, and R.sub.3 =H or R.sub.2 +R.sub.3 =chemical bond; R.sub.4 =C.sub.1 -C.sub.4 hydrocarbon; R.sub.5, R.sub.6, R.sub.8, R.sub.9 independently=H, C.sub.1 -C.sub.4 alkyl, or R.sub.5, R.sub.8 independently=H, C.sub.1 -C.sub.4 alkyl and R.sub.6 +R.sub.9 =CH.sub.2 CH.sub.2, CH.sub.2 CH.sub.2 CH.sub.2 ; R.sub.7 =H, C.sub.1 -C.sub.4 alkyl, phenyl, NR'R'; R',R' independently=H, C.sub.1 -C.sub.4 alkyl, acyl or NR'R'=heterocyclic ring; W=0, H.sub.2 ; n=0, 1, 2, and their pharmaceutically acceptable salts, these compounds exhibiting antihypertensive activity making them useful anxiolytic and antipsychotic agents. A process for their preparation and pharmaceutical compositions containing them are also described.

3-oxo-piperazin-1-yl-ergolines exhibiting antidopaminergic activity

There are provided compounds of formula 1: ##STR1## wherein R=halogen atom or CN, NH.sub.2 and NO.sub.2 group, and pharmaceutically acceptable salts thereof. The compounds are antipsycotic agents.

Antipsycotic benzoxazines

Compounds of the formula: ##EQU1## wherein R and R' are lower alkyl groups having from 1 to 4 carbon atoms, eventually substituted by a hydroxyl group; n is an integer from 0 to 3 and R' together with the ##EQU2## group jointly represent the group ##EQU3## A process for the preparation of these compounds is also disclosed. The compounds of the invention display interesting pharmacological activities and may be usefully employed as antidepressants.

4H-1,3-benzoxazin-2-one-3-acetohydroxamic acid derivatives

Growing community of inventors

Milan, Italy

Lorenzo Pegrassi