Chemi S.p.a.

Italfarmaco Sud S.p.a.

Other

Chemi Nutra, LLC

Chem Spa

Italfarmaco Spa

Lorenzo De Ferra

Pietro Massardo

Maurizio Zenoni

Stefano Turchetta

Oreste Piccolo

Mauro Anibaldi

Umberto Ciambecchini

Elio Ullucci

Barbara Pinto

Ettore Ammirati

Annamaria Naggi

Fausto Bonifacio

Stefano Servi

Paolo Brandi

Mara Sada

Martin Purpura

Tiziana Benincori

Giorgio Cignarella

Angela Tuozzi

Scott L Hagerman

Alessandra Verrazzani

Vincenzo De Sio

Giorgio Berardi

Andrea Stevenazzi

Fabrizio Cocchi

Patrizia R Mussini

Sandra Rondinini

Guido Cifarelli

Marvin Heuer

Simona Rizzo

Simona Tollis

Simona Andreassi

Mauro Annibaldi

Francesco Sannicolo′

Paolo Casellato

Daniele Scorretti

Ezio Fasoli

Luca Mandelli

Felice Stracqualursi

A method for the qualification and selection of manufacturing processes, raw materials, intermediates and batch production of pentosan polysulfate based on the identification of acetylated monosaccharide units, including units of xylose substituted with 4-O-methyl-glucuronic which also lead the acetyl group, as structural characterizing units, is disclosed.

Method for the qualification of preparations of pentosan polysulfate, raw materials and production processes thereof

Phosphatidic acid is administered orally to increase muscle mass and strength in exercising mammals. Phosphatidic acid is administered orally to aging, bedridden or cachectic patients to improve nitrogen balance. The preferred form of phosphatidic acid for administration is phosphatidic acid-enriched lecithin. Creatine is co-administered orally to increase the muscle-building and strength effect. Other suggested additives include nutritional and herbal supplements, micronutrients and hormones.

Method for increasing muscle mass and strength

The present invention relates to a process for the preparation of a polysaccharide composed of D-xylose units of formula (III) linked together via beta 1,4 glycosidic bonds wherein Ris hydrogen or acetyl, Ris hydrogen, acetyl or a 4-O-methyl glucuronic acid unit, wherein, when Ris a 4-O-methyl glucuronic acid unit, the Rgroup on the same saccharide unit is defined as G, wherein G is hydrogen or acetyl, and wherein the sugar unit at the reducing end of sun such polysaccharide is xylose, lyxose or xylulose, said process comprising the following steps: selective deacetylation of xylan extracted from beech wood; and isomerization of the selectively deacetylated xylan achieved in step or the following steps: isomerization of xylan extracted from beech wood; and selective deacetylation of isomerized xylan achieved in step. The process is useful for the preparation of pentosan polysulfate or pharmaceutically acceptable salts thereof for pharmaceutical use.

Process for the preparation of polysaccharides

A process for the purification of L-&#x3b1;-glycerophosphorylcholine is described, wherein L-&#x3b1;-glycerophosphorylcholine is crystallized from DMSO or from a mixture of DMSO with at least another solvent, preferably selected from water, alcohol, halogenated solvents, ethers, esters and/or amides. Such a process allows to obtain L-&#x3b1;-glycerophosphorylcholine having a purity greater than 99.5%, preferably greater than 99.7%, even more preferably greater than or equal to 99.9%. A method for determining the purity of L-&#x3b1;-glycerophosphorylcholine is also described, comprising the elution of L-&#x3b1;-glycerophosphorylcholine through an HPLC column having an amino stationary phase, and subsequent detection of L-&#x3b1;-glycerophosphorylcholine itself, and any impurity thereof, by means of an Evaporative Light Scattering Detector type.

Process for the purification of L-&#x3b1;-glycerophosphorylcholine

Described herein is a process for the synthesis of azacitidine or decitabine, comprising the silylation of azacytosine in the presence of N,O-bis-trimethylsilyl-trifluoroacetamide. Such reaction is performed in an organic solvent, preferably aprotic, even more preferably selected from among dichloromethane, dichloroethane and/or acetonitrile. According to a further aspect of the process, 2 to 3 moles of N,O-bis-trimethylsilyl-trifluoroacetamide are used per mole of azacytosine, preferably from 2.2 to 2.5.

Process for the synthesis of azacitidine and decitabine

A process for the preparation of a prodrug of 5-aminosalicylic acid, namely 2-butanoyloxy-5-amino-benzoic acid, and solid forms of such compound are described.

Prodrug of an anti-inflammatory active ingredient

The present invention relates to a novel process for the preparation of pemetrexed diethyl ester 2 by purifying the mixture obtainable by reacting compounds 1 and 1a in the presence of a chemical agent capable of promoting the formation of a peptide bond in an aprotic organic solvent characterized in that the mixture is subjected to the following steps:

Process for the synthesis of pemetrexed disodium salt

The present invention regards an improved and industrially advantageous process for the preparation of the 2-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl-methanol intermediates, also called 'feso chromenyl' and (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol, also called '(R)-feso deacyl', which are in turn used in the synthesis of fesoterodine and in particular of fesoterodine fumarate. This process utilises reagents which are non-toxic and manageable at industrial level and enables obtaining a new stable and non-hygroscopic crystalline form of the key intermediate &#x201c;(R)-feso deacyl&#x201d;, called form B.

Process for the preparation of 2-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl-methanol and (R)-feso-deacyl

The document describes a process for the preparation of N-Acyl-Phosphatidyl-Ethanolamine of formula (I) on an industrial scale, In which R, Rand Rare, independently from each other, saturated, monounsaturated or polyunsaturated acyls C-C, pure or mixed together, and X&#x2550;OH or OM, where M=alkaline metal or alkaline earth, ammonium or alkylammonium. The process in question allows the conversion of lecithin of synthetic or natural origin into N-Acyl-Phosphatidyl-Ethanolamine of formula (I) of high purity, using a limited molar excess of the reagent N-acyl-ethanolamine, where the acyl is as defined above for the formula (I) through reaction of transphosphatidylation in the presence of the enzyme phospholipase D and in conditions suitable for production on an industrial scale. 

Process for the production of N-acyl-phosphatidyl-ethanolamine

The present invention relates to a purifying process for phosphatidylserine, the latter being prepared by trans-phosphatidylation of phosphatidylcholine with serine in presence of the enzyme D-phospholipase and containing as impurities hydrophilic compounds, proteins and inorganic salts.

Purifying process for phosphatidylserine

Described is a new process for producing temozolomide, comprising the reaction between 5-aminoimidazole-4-carboxamide and N-succinimidyl-N'-methyl carbamate and the subsequent reaction of the thus obtained carbamoyl 5-aminoimidazole-4-carboxamide with sodium nitrite. Temozolomide is then purified by chromatography on adsorbent polymeric resin and subsequent crystallization from water and acetone.

Process for preparing temozolomide

Process for preparing lysophosphatidylcholine by selective monoacylation of glycerophosphorylcholine (1), in the presence of an acylating agent and of a dialkyltin derivative, according to the following diagram:  The process is particularly simple and has high overall yields.

Process for preparing lysophosphatidylcholine

The present invention relates to a process for the preparation of Montelukast and the salts thereof comprising the following steps: (a) reaction of a compound A with a compound A in which n varies between 1 and 2 and, when n is 1, R is methyl and, when n is 2, R is a C-Calkyl or an aryl, and X is a leaving group, by nucleophilic substitution reactions in dipolar organic solvents to yield the compound A3 (b) reaction of the compound A3 with an inorganic acid HY, in which Y is Cl, Br, I, and subsequent isolation of the resultant salt A4; (c) optional conversion of the salt A4 into the compound A3;(d) methylation of the salt A4 and/or of the compound A3 to yield Montelukast.

Process for the preparation of Montelukast

A process for preparing alendronate sodium includes the reaction of gammabutyric acid with phosphorous acid and phosphorus trichioride and subsequent treatment with an aqueous solution of an alkali metal hydroxide, in which the reaction is conducted in liquid ionic solvents.

Preparation of biphosphonic acids and salts thereof

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Patrica, Italy

Lorenzo De Ferra