Julius-maximilians-universitaet Wuerzburg

Julius-maximilians-universitaet

Thommen Medical Ag

Julius-maximilians-universitat Wurzburg

Lorenz Meinel

Matthias Schnabelrauch

Falko Schlottig

Ralf Wyrwa

Juergen Seibel

Christoph Steiger

Christian Wunder

Martina Raschig

Tessa Luehmann

Thomas Seemann

Claudia Rode

Jennifer Ritzer

Tobias Miesler

Tessa Lühmann

Alexandra Braun

It is an object of the present invention to introduce carboxylic acid-functionalities suitable for coupling into the denatonium structure by means of simple synthesis, namely the synthesis of bitter principle derivatives based on the denatonium structure according to formula 1: For example, according to the invention, lidocaine derivatives may be reacted with carboxylated benzyl halogenides. The carboxylated denatonium derivatives of the present invention are especially applied in medicine, biology, medical engineering as well as cosmetics, the pharmaceutical, chemical, and foodstuff industry.

Production of bitter principle derivatives

The present invention is directed to compounds of the general formula (I) and salts thereof wherein Xis halide, pseudohalide, sulphate, benzoate, acetate, trifluoroacetate, hydroxide, saccharinate or capsaicinate; Ris hydrogen or C1-C10-alkyl; and R-Rindependently are hydrogen, halogen, C1-C5-alkyl, C1-C4-alkoxy, C1-C20-alkoxycarbonyl. The invention is furthermore directed to a method for the preparation of these compounds. The compounds can be used as bitter substances in medicine, pharmaceutics and/or diagnostics. They can furthermore be used for the coupling to proteins and peptides by means of forming a peptide bond between the amino-group of the compounds of the present invention and a carboxyl-group of the protein or peptide.

Aminomethyl-functionalized denatonium derivatives, their preparation and use

The present invention relates to a gas delivery device comprising a gas releasing molecule and a gas permeable membrane. The invention also relates to the use of the gas delivery device for delivery of gas to an extracorporeal transplant, extracorporeal cells, a brain-dead transplant donor or foodstuff and in therapy. The invention further relates to the use of a gas permeable and liquid and solid impermeable membrane to separate a gas releasing molecule and its non-gaseous degradation products from an extracorporeal transplant, extracorporeal cells, a brain-dead transplant donor or foodstuff.

Gas delivery device comprising a gas releasing molecule and a gas permeable membrane

The document proposes a diagnostic chewing gum for identifying the presence of inflammatory tissues in the mouth, in particular in or adjacent to the mandible, the maxilla, an implant or the teeth of a user, comprising a base material or particles () embedded and/or attached to the base material; an element (,-), like e.g. a releasable flavor molecule, attached to the base material and/or the particles, for the generation of a change in the chewing gum directly detectable by the user; wherein the element (,-) generates the change upon direct or indirect contact with a marker (), e.g. a proteolytic enzyme, which is released by inflammatory tissue in response to bacterial mediators.

Device for the diagnosis of inflammatory tissues in dental applications

Described herein is a diagnostic chewing gum for identifying the presence of pathogens detectable via the mouth, in particular pathogens residing in nasal, oropharyngeal, laryngeal, oesophageal, ocular and/or pulmonal tissue of a user, more particularly pathogens selected from among a virus, bacterium, protozoa, prion, fungus or a combination thereof. The inventive diagnostic chewing gum includes a base material or particles () embedded and/or attached to the base material and an element (-), like e.g. a releasable flavor molecule, attached to the base material and/or the particles, for the generation of a change in the chewing gum directly detectable by the user, wherein the element (-) generates the change upon direct or indirect contact with a marker () which is released by the pathogens, or, in case of a virus or prion, by the cellular structure hosting it.

Diagnostic chewing gum for pathogens

Growing community of inventors

Wuerzburg, Germany

Lorenz Meinel