Pfizer Corporation

Loren Michael Price

Matthew Frank Brown

Ye Che

Justin Ian Montgomery

Usa Reilly

Mark Stephen Plummer

Michael Joseph Melnick

Richard Andrew Ewin

Timothy Allan Johnson

Tamim F Braish

Michael Joesph Melnick

Daniel Paul Uccello

Mathew Frank Brown

The present invention is directed to a new fluoro-pyridinone hydroxamic acid phosphates and boronates of Formulae I, II and III wherein Q is selected from the group consisting of —P(O)(OH), —P(O)(OH)(OM), —P(O)(OM)and —P(O)(O)M; Mat each occurrence is a pharmaceutically acceptable monovalent cation; and Mis a pharmaceutically acceptable divalent cation and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Fluoro-pyridinone phosphates and boronates useful as antibacterial agents

The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Fluoro-pyridinone derivatives useful as antibacterial agents

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Groton, CT, United States of America

Loren Michael Price