The Burnham Institute

Loredana Fiorentino

John C Reed

Adam Godzik

Krzysztof Pawlowski

Zhi-Liang Chu

Christian Stehlik

Sug Hyung Lee

Frank Stenner-Liewen

Maria Eugenia Ariza

Wilfried Roth

In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.

Death domain proteins

The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NB-ARC domains and LRR domains, encoded polypeptides, and antibodies. Also provided are methods of identifying polypeptides and agents that associate with a PAAD-domain containing polypeptide or fragment thereof, or that alter an association of a PAAD domain-containing polypeptides. Further provided are methods of identifying agents that modulate PAAD domain-mediated inhibition of NF&#x3ba;B activity, or modulate an activity of an NB-ARC domain of a PAAD domain-containing polypeptide. Also provided are methods of modulating NF&#x3ba;B transcriptional activity in a cell, and methods of altering expression of a PAAD domain-containing polypeptide in a cell.

Nucleic acid molecule encoding a PANG6 polypeptide

Growing community of inventors

San Diego, CA, United States of America

Loredana Fiorentino