Istituto Biochimico Italiano Giovanni Lorenzini S.p.a.

Instituto Biochimico Italiano Giovanni Lorenzini S.p.a.

Loredana Cecchetelli

Alberto Brandt

Giordano Bruno Corsi

Antonio Simeoni

The present invention refers to the preparation process of the sodium salt of 6&lsqb;D-(&minus;)&agr;-4-(ethyl-2,3-dioxo-1-piperazinocarbonylamino) phenylacetamido&rsqb;penicillanic acid, comprising the reaction of the acid with a reagent selected from the group consisting of sodium hydroxide, sodium carboxylates and sodium alcoholates, followed by a separation step of the so obtained sodium salt by precipitation.

Process for the preparation of the sodium salt of 6&lsqb;D-(-)&agr;-4-(ethyl-2,3-dioxo-1-piperazinocarbonylamino)phenylacetamido&rsqb;penicillanic acid

A process for the preparation of sterile sodium amoxycillin characterized by the fact that a solution of amoxycillin trihydrate in a mixture of methyl alcohol and a lower C.sub.2 -C.sub.5 alcohol is reacted in a sterile ambient, optionally in the presence of a suitable amine, with a solution of a suitable salifying agent selected from the group consisting of an alcoholate or carboxylate of sodium in methyl acetate followed by separation of the precipitate is described.

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Genzano, Italy

Loredana Cecchetelli