Argenx Bvba

Universitè Catholique De Louvain

Tetragenetics, Inc.

Université Catholique De Louvian

Lore Mariën

Pierre G Coulie

Torsten Dreier

Sophie Lucas

Sebastian Paul Van Der Woning

Gitte De Boeck

Filip Borgions

Stéphanie Liénart

William Don Harriman

Hans De Haard

Paul A Colussi

Ellen J Collarini

Theodore G Clark

Ashot Papoyan

Yelena Bisharyan

Douglas Kahn

Bas Van Der Woning

Alka Agrawal

Janna Bednenko

Stëphanie Liénart

Joanna Cardarelli

Anti-Kv1.3 antibodies (mAbs), particularly mAbs that specifically bind to Kv1.3 with high affinity and/or inhibit Kv1.3 function, are disclosed. The amino acid sequences of the CDRs of the light chains and the heavy chains, as well as consensus sequences for these CDRs, of these anti-Kv1.3 mAbs are provided. Additionally, canonical structures for CDRs in the VH and VL regions of anti-Kv1.3 antibodies are provided. The disclosure also provides nucleic acid molecules encoding the anti-Kv1.3 mAbs, expression vectors, host cells, methods for making the anti-Kv1.3 mAbs, and methods for expressing the anti-Kv1.3 mAbs. Finally, methods of using the anti-Kv1.3 mAbs as therapeutics, such as for preventing or treating an autoimmune disorder, are disclosed.

Anti-Kv1.3 antibodies, and methods of production and use thereof

The present invention relates to antibodies and antigen binding fragments thereof, which bind to a complex of GARP and TGF-&#x3b2;1, particularly a complex of human GARP and human TGF-&#x3b2;1. These antibodies and antigen binding fragments exhibit a combination of advantageous properties including high affinity antigen binding and the ability to inhibit the release of active TGF-&#x3b2; from regulatory T cells. The antibodies and antigen binding fragments of the present invention are relatively resistant to deamidation, isomerization and oxidation, such that they display improved stability.

Nucleic acids encoding GARP-TGF-beta 1 antibodies

GARP-TGF-&#x3b2; 1 IGG antibodies

GARP-TGF-beta 1 antibodies

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Ghent, Belgium

Lore Mariën