Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Lorand Farkas

Mihaly Nogradi

Agnes Gottsegen

Laszlo Feuer

Sandor Antus

Todor Pfliegel

Borbala Vermes

Andras Wolfner

Nonestrogenic 5-methyl-alkoxy-isoflavone, namely, 5-methyl-7-methoxy-isoflavone, 5-methyl-7-ethoxy-isoflavone, 5-methyl-7-isopropoxy-isoflavone, and 5-methyl-7-(2-hydroxy-ethoxy)-isoflavone are useful as weight-gain promoters in feeds from which the 7-methoxy and 7-ethoxy isoflavones have been excluded because of estrogenic effects. They are more effective than 7-isopropoxy-isoflavone as well.

Metabolic 5-methyl-isoflavone-derivatives, process for the preparation

Compounds of the formula (1), or their salts, ##STR1## are prepared as follows: (A) A COMPOUND OF THE FORMULA (II) ##STR2## is reduced; or (B) A COMPOUND OF THE FORMULA (III) ##STR3## is reacted, e.g. after protecting the phenolic hydroxy group attached to position 3 of the ring, with a compound of the formula (IV), ##STR4## or (C) GROUP R.sup.1 of a compound of the formula (V) ##STR5## is removed in an acidic medium, AND, IF DESIRED, THE COMPOUND OF THE FORMULA (I) is converted into salt, or a salt of a compound of the formula (I) is converted into the free acid or another salt thereof. The compounds of the formula (I) and their salts are valuable artificial sweetening agents. In the above formulae

Acyl-phenoxy-propanesulfoacids and salts, and artificial sweetening

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Budapest, Hungary

Lorand Farkas