Other

Monsanto Company

Loraine Klein

Robert W Erickson

David R Allen

Diane Froen

Dennis A Seagle

Scott Jenkins

Ron Bray

Mark Johnson

Methods for preparing (S)-N-tert-butyl-1,2,3,4-tetrahydro-3-isoquinoline-carboxamide ('tic-c'), and converting tic-c to (S)-decahydroisoquinoline-3-carboxylic acid t-butylamide ('tic-d') are disclosed. The initial step in the formation of tic-c involves the phosgenation of a substituted tetrahydroisoquinoline to form an N-carboxy anhydride. Tic-d is used as an intermediate in the synthesis of known compounds having pharmaceutical activity.

Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-butylamide

The present invention is an improved process for the synthesis of asparagine, a non-essential amino acid useful in food and medical applications. The process utilizes mineral acid to make an intermediate beta-methyl aspartate from a reaction mixture of aspartic acid and methanol. The intermediate product is then amminated in situ and asparagine collected with no need for an isolation step of the intermediates.

Process for the preparation of asparagine

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Streamwood, IL, United States of America

Loraine Klein