Celtaxsys, Inc.

Celltaxis, LLC

Lopa Bhatt

Eric B Springman

William J Guilford

Ralph Grosswald

Kurt Roinestad

Tom Kirkland

Margaret McCrann Pugh

Jonathan L Moon

Milton Henry Werner

Erica Brook Goodhew

Stacey L Rose

Surendra Chavan

Hyun Kang

Scott Sacane

The present invention is directed to methods of inhibiting LTA-h in a human patient and method of treating a condition ameliorated by the inhibition of leukotriene Ahydrolase activity in a human patient comprising administering to said human patient the compound, 4-{5-[4-(4-Oxazol-2-yl-phenoxy)-benzyl]-2,5-diaza-bicyclo[2.2.1]hept-2-ylmethyl}-benzoic acid.

Methods of inhibiting leukotriene A4 hydrolase

This present disclosure is directed to compounds of formula (I): 

Monamine and monoamine derivatives as inhibitors of leukotriene A4 hydrolase

This present disclosure is directed to compounds of formula (I):  where R, R, Y, and Z are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene Ahydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions including the compounds described herein and methods of preparing the compounds described herein are also provided.

Inhibitors of leukotriene A4 hydrolase

Pendant amines and derivatives as inhibitors of leukotriene A4 hydrolase

The present invention provides compositions and methods of controlling the direction and/or movement of migratory cells. Specifically, the invention is directed to the identification of novel chemorepellents and unimodal fugetaxins, their agonists and antagonists which alter or affect the movement of cells involved in immune, inflammatory or cancerous phenotypes.

Chemorepulsion of cells

The current invention is directed to methods of inducing migration of an immune cell toward a cancer cell comprising inhibiting the activity of a chemorepellant released from the cancer cell.

Methods of modulating the negative chemotaxis of immune cells

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Roswell, GA, United States of America

Lopa Bhatt