Guangzhou Cellprotek Pharmaceutical Co., Ltd

Longxiang Sheng

Guangmei Yan

Wei Yin

Bingzheng Lu

Yuan Li

Suizhen Lin

Yijun Huang

Provided are applications of a hexokinase 2-specific inhibitor in preparing a medicament for preventing and treating acute central nervous system injury.

Hexokinase 2-specific inhibitors for use in acute central nervous system injury

Disclosed is use of 5α-androst-3β,5,6β-triol or an analogue, a deuterated compound or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of cerebral small vessel disease in a patient. The cerebral small vessel disease is preferably cerebral microbleed. The cerebral microbleed is spontaneous cerebral microbleed, drug-related cerebral microbleed, or traumatic cerebral microbleed. The present invention demonstrates that these compounds significantly enhance the clearance of extravascular hemoglobin, and thus can be used to treat cerebral small vessel disease.

Use of compound in preparation of drug for treating cerebral small vessel disease

Growing community of inventors

Guangdong, China

Longxiang Sheng