Emory University

Cocrystal Pharma, Inc.

Rfs Pharma LLC

University of Pittsburgh

Longhu Zhou

Raymond F Schinazi

Steven J Coats

Hongwang Zhang

Franck Amblard

Richard Anthony Whitaker

Junxing Shi

Tamara Rosario McBrayer

Jong Hyun Cho

Christina Gavegnano

John W Mellors

Bryan D Cox

Nicolas Paul Sluis-Cremer

Leda Bassit

Brian David Herman

The present invention is directed to compounds, compositions and methods for treating or preventing Zika virus. The compounds include pyrimidine and purine nucleosides and prodrugs thereof, including certain N-hydroxycytidine nucleoside derivatives, sulfasalazine, and various entry inhibitors.

Antiviral agents and nucleoside analogs for treatment of Zika virus

The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as also pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof as pharmaceutical compositions and methods for treatment or prevention of HCV infection.

Potent and selective inhibitors of hepatitis C virus

The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV in human patients or other animal hosts. The compounds are certain 6-substituted purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1, HIV-2, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV.

Purine nucleoside monophosphate prodrugs for treatment of cancer and viral infections

The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, and HBV, in human patients or other animal hosts. The compounds are 3'-azido-2&#x2032;,3&#x2032;-dideoxy purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1 and HBV.

3'-azido purine nucleotide prodrugs for treatment of viral infections

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Atlanta, GA, United States of America

Longhu Zhou