The General Hospital Corporation

Kentucky Bioprocessing, Inc.

Long V Nguyen

Howard M Goodman

John A Lindbo

Gregory P Pogue

Lin Sun

Kenneth E Palmer

Mark L Smith

Alison A McCormick

Yun Lin

Herein-described are various methods for making a vaccine that are made of re-assembled virus like particles (VLP). First, the VLPs are disassembled into encapsidation intermediate populations. Each encapsidation intermediate population undergoes, for instance, chemical conjugation of unique peptide or nucleic moieties to form separate populations. Thereafter, a predetermined amount of each of the several (one or more) different encapsidation intermediates from the different populations is mixed and joined, forming intact VLPs, surrounding a nucleic acid core, that are composed of different encapsidation intermediate such that the reassembled VLP displays more than one peptide or nucleic acid. The nucleic acid can function either as a scaffold alone or can be engineered for the expression of an immunomodulatory protein in a eukaryotic cell.

Flexible vaccine assembly and vaccine delivery platform

Disclosed is asse1 gene, which is responsible for protein and oil body biogenesis. The invention further provides methods for using the disclosed gene for modifying the components of plant storage reserve materials.

Nucleic acid encoding the arabidopsis SSE1 protein and a method of using it to modify plant storage reserves

Growing community of inventors

Vacaville, CA, United States of America

Long V Nguyen