Sanofi

Sanofi-synthelabo

Elf Sanofi

Loic Foulon

Gerard Valette

Georges Garcia

Claudine Serradeil-Le Gal

Claudine Serradeil-Legal

Dino Nisato

Jean Wagnon

Richard Roux

Alain Di Malta

Alain Pellet

Bernard Christophe

Daniel Mettefeu

Claudine Serradeil-Le-Gal

Cedric Couturier

The subject matter of the present invention are compounds corresponding to formula (I):  in which: X is an unsubstituted or substituted divalent (C-C)alkylene radical; Ris an &#x2014;NRRgroup; or an unsubstituted or substituted piperidin-3-yl or piperidin-4-yl radical; Ris a hydrogen atom, a halogen atom, an Alk group or an OAlk group; Ris a hydrogen atom, a halogen atom, an Alk group or an OAlk group; Ris a hydrogen atom, a halogen atom, an Alk group, a hydroxyl or an OAlk group; and Ris a hydrogen atom, a halogen atom, an Alk group, a hydroxyl or an OAlk group.

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Indolin-2-one derivatives, method for preparing them and pharmaceutical

The subject of the invention is indolin-2-one derivatives of formula: ##STR1## in which: W represents a --CH.sub.2 -- or --SO.sub.2 -- group;

3-spiro-indolin-2-one derivatives

3-spiro-indolin-2-one derivatives as vasopressin and/or oxytocin

The invention relates to 1-Benzenesulfonyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## and their salts, where appropriate, to their preparation and to pharmaceutical compositions in which they are present. These compounds have an affinity for the vasopressin and/or ocytocin receptors.

1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their

1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation

1-benzenesulfonyl-1,3-dihydroindol-2-one derivatives, their preparation

The subject of the invention is the compounds of formula I ##STR1## in which Ar.sub.1 represents naphtyl, phenyl, quinolyl or isoquinolyl optionally substituted;

Compounds bearing sulphamoyl and amidino radicals, their preparation

The present invention relates to 1-benzyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## to their preparation and to the pharmaceutical compositions in which they are present. These derivatives have an affinity for the vasopressin and oxytocin receptors.

1-benzyl-1,3-dihydroindol-2-one derivatives, their preparation and the

A compound of formula I ##STR1## in which Ar.sub.1 is naphthyl and phenyl, quinolyl or isoquinolyl optionally substituted; Ar.sub.2 is phenyl or thienyl optionally substituted; R.sub.1, R.sub.2 and R'.sub.2 are independently of each other H or (C.sub.1 -C.sub.4)alkyl or R.sub.1 represents a bond and N is covalently bonded to Ar.sub.2, and optionally R.sub.2 and R'.sub.2 form a double bond, or R.sub.1 or R.sub.2 is covalently bonded to Ar.sub.2 and represents a (C.sub.1 -C.sub.3 )alkylene; R.sub.3 and R.sub.4 are independently of each other H or (C.sub.1 -C.sub.4)alkyl or form, with the nitrogen atom to which they are attached pyrrolidine, ppiperidine, or hexahydroazepine; Z.sub.1 represents (C.sub.1 -C.sub.12)alkylene, optionally interrupted by a radical selected from the group consisting of (C.sub.5 -C.sub.7)cycloalkyl and phenyl or substituted with a radical selected from the group consisting of (C.sub.5 -C.sub.7)cycloalkyl and phenyl; Q.sub.1 is selected from the group consisting of methyl, amino, (C.sub.1 -C.sub.4)alkoxycarbonylamino, (C.sub.1 -C.sub.4)alkylamino, di(C.sub.1 -C.sub.4)-alkylamino, pyrrolidinyl, piperidino, morpholino, piperazinyl, 4-(C.sub.1 -C.sub.4)alkylpiperazinyl, amidino, (C.sub.1 -C.sub.4)-alkylamidino, guanidino, (C.sub.1 -C.sub.4)alkylguanidino, pyridyl, imidazolyl, pyrimidinyl, indolyl, hydroxy,(C.sub.1 -C.sub.4)alkoxy,(C.sub.2 -C.sub.8)alkoxycarbonyl,N-�amino(C.sub.1 -C.sub.4)alkyl!-N-�(C.sub.1 -C.sub.4)alkyl!amino, carbamoyl, phenyl and phenyl substituted by a radical selected from the group consisting of Cl, F, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy and hydroxyle; Q.sub.2 is selected from the group consisting of H and (C.sub.1 -C.sub.4)alkyl; Q.sub.3 is selected from the group consisting of H and (C.sub.1 -C.sub.4)alkyl or Q.sub.1 and Q.sub.3 are attached to form a heterocycle and together represent (C.sub.2 -C.sub.3)alkylene, whereas Z.sub.1 represents a bond, in the form of pure enantiomer or mixture thereof in any proportions as well as its salt with acid.

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