Shimadzu Corporation

Cnh Industrial Italia S.p.a.

Logan Miller

Yuka Fujito

Mark Allan Renard

Christopher Brosz

Eric Olson

A liquid chromatograph includes at least one mobile phase supply flow path (), at least one cleaning solution supply flow path () joining the mobile phase supply flow path (), an analysis flow path () provided with a separation column (), a sampling flow path () provided, at a tip end thereof, with a sampling needle (), a switcher () including a high-pressure valve () having an injection port () and configured to switch a flow path configuration of the liquid chromatograph between a loading state in which the analysis mobile phase supply flow path () and the analysis flow path () are connected in a fluid manner without the sampling flow path () and an injecting state in which the sampling flow path () is interposed between the analysis mobile phase supply flow path () and the analysis flow path () when a tip end of the needle () is inserted into the injection port (), and a controller () configured to execute, when a predetermined condition is satisfied, the cleaning operation of supplying the mobile phase and the cleaning solution to the analysis flow path () and/or the sampling flow path () to temporally change the composition of liquid flowing in the analysis flow path () and/or the sampling flow path ().

Liquid chromatograph and flow path cleaning method in liquid chromatograph

A controller of a liquid chromatograph is configured to execute, as an analysis operation in an analysis unit, a sample injection step of bringing a high-pressure valve into a loading state, sucking a sample from a tip of a needle to hold a sample in a sampling channel, then connecting the sampling channel to an injection port and bringing the high-pressure valve into an injecting state, and supplying a mobile phase from a liquid supplier, thereby injecting a sample held in the sampling channel into an analysis channel, and an analysis step of separating components of a sample injected into the analysis channel in a separation column by bringing the high-pressure valve in the loading state and supplying the mobile phase from the liquid supplier after the sample injection step is ended. The controller is configured to execute, as the analysis operation, a system cleaning step of cleaning a liquid flowing route.

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Columbia, MD, United States of America

Logan Miller