Achaogen, Inc.

Revagenix, Inc.

Logan Andrews

Ryan Cirz

Michael J Lopez

Frederick Cohen

Timothy Robert Kane

Andrew Calabrese

Nikolai Evdokimov

Daniel John Cloutier

Allison Seiko Komirenko

Ian Friedland

John Knox

Adrian Jubb

Kevin Michael Krause

Provided herein are aminoglycoside compounds, such as compounds of formula (I), (II), (III), (IV), (IVa), (V), (VI), (VIIa), or (VIIb) or pharmaceutically acceptable salts, solvates, stereoisomers, or tautomers of any of the foregoing, useful as therapeutic or prophylactic agents. Also provided herein are methods for their preparation. The compounds may be useful in treating a bacterial infection in a subject, for example a Gram-negative bacterial infection.

Aminoglycosides and uses thereof

Provided herein are methods of treating a bacterial infection, wherein the methods comprise administering (a) ceftibuten or a pharmaceutically acceptable salt thereof, or a hydrate of the foregoing; and (b) clavulanic acid, or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions, articles of manufacture, and kits comprising a) ceftibuten or a pharmaceutically acceptable salt thereof, or a hydrate of the foregoing; and (b) clavulanic acid, or a pharmaceutically acceptable salt thereof, and uses thereof.

Combination products for the treatment of bacterial infections and methods of producing or dosing of same

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San Mateo, CA, United States of America

Logan Andrews