Universiteit Gent

Vib Vzw

Loes Van Schie

Nico Callewaert

Joris Delanghe

Bram Laukens

Elisabeth Van Aken

Wander Van Breedam

Wim Nerinckx

The present invention provides nucleotide sequences encoding polypeptides comprising immunoglobulin variable domains with engineered glycosylation acceptor sites. Specifically, the invention provides immunoglobulin variable domain proteins modified with selected glycans and specific glycan-conjugates thereof. Also provided herein are methods for the production of glycosylated immunoglobulin variable domains and glycan-conjugates thereof.

Glycosylation of variable immunoglobulin domains

A non-surgical treatment of cataract in a human or animal. The invention specifically relates to the administration of a deglycating enzyme and its cofactor(s), which results in the deglycation of the lens crystallins. The disclosure thus relates to a minimal invasive type of treatment of cataract, which is easier and cheaper compared to existing surgical methods.

Compositions for use to treat cataract

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Ghent, Belgium

Loes Van Schie