Semen Refinement B.v.

Nanomed Diagnostics Bv

Loes Irene Segerink

Albert Van Den Berg

Roderik Adriaan Kraaijenhagen

Adrianus J Sprenkels

Wouter Olthuis

Renske Daniëla Maria Steenbergen

Herbert Michael Pinedo

Willem Frederik Rurup

Idris Bahce

Bjorn De Wagenaar

Geert Kazemier

Jacobus Adrianus Nieuwenhuijzen

Adrianus Joseph Sprenkels

Van Den Albert Berg

The invention provides in vitro methods of determining whether an individual has a pre-cancer or cancer comprising determining the presence or absence of one or more methylation markers of a methylation marker set in a urine sample of said individual; and determining whether the individual has pre-cancer or cancer based on the detection of the presence or absence of said one or more methylation markers in the urine sample, wherein the presence of said one or more methylation markers indicates that the individual has pre-cancer or cancer. The invention further provides methods for typing pre-cancer or cancer based on the the presence or absence of one or more methylation markers of a methylation marker set in a urine sample.

Detection of cancer in urine

The invention provides a system () for performing sperm analysis and selection based on sperm cell morphology of sperm cells () in a fluid (), the system () comprising: (i) a fluid flow channel () for transport of said fluid (), the fluid flow channel () comprising an inlet () an analyzing zone () configured downstream from said inlet () and comprising a first pair of electrodes () comprising a first intra-electrode distance (dl), a sorting zone () configured downstream from said analyzing zone () and comprising a sorting device (), and outlets (, . . . ) configured downstream from said sorting zone (); (ii) an electric source () configured to provide an electric signal to the first pair of electrodes (); (iii) a measuring device () functionally coupled to the first pair of electrodes () and configured to measure a first impedance as a function of time of the fluid () between the first pair of electrodes, and to provide time-dependent impedance data; wherein the sorting device () is configured to sort sperm cells () by directing the sperm cell () in the sorting zone () to one of the outlets (, . . . ) based on a comparison in a comparison stage of the time dependent impedance data with predefined reference data.

Microfluidic device for selection of semen

Growing community of inventors

Enschede, Netherlands

Loes Irene Segerink