Smylio Inc.

Oxular Limited

Loc Phan

Renjith Menon

John P Lunsford

Stanley R Conston

Robert Steven Bley

Tien Thuy Nguyen

Ronald K Yamamoto

Nichole Garcia

Huong Dinh

Dillon Daniel Martinez

An orthodontic appliance is constructed from shells shaped to receive teeth. The shells can be constructed from one or more polymer materials and affixed to one another about the edge of each shell, defining a narrow elongate chamber therebetween. The chamber serves to allow for the first shell contacting the teeth to flex and fit a wide range of teeth without sacrificing the overall flexural modulus of the appliance. Methods of making the appliance are also described.

Elastic orthodontic appliances, systems, and methods for use

Orthodontic appliances formed from a material that includes an interpenetrating polymer network or semi-interpenetrating polymer network material to prevent or reduce stress relaxation of the material during use by a patient. Methods for forming orthodontic appliances from a material that includes from an interpenetrating polymer network or semi-interpenetrating polymer network material to prevent or reduce stress relaxation of the material during use by a patient.

Stress relaxation resistant orthodontic appliances

The present invention provides a drug composition comprising particles comprising a biodegradable or bioerodable polymer and a drug, a soluble, biodegradable or bioerodible excipient, a bulking agent and a reconstitution aid. The invention also provides a pharmaceutical formulation and a unit dosage form of the pharmaceutical formulation. The invention provides methods of treatment of a disease or condition accordingly. The invention also provides a drug composition for use in a cannulation device.

Ophthalmic drug compositions

A system with a saliva sampling device configured to be orally worn by a patient. The saliva sampling device is a polymer retainer or aligner. A saliva analysis engine is used to correlate one or more analytes of one or more saliva samples with one or more health attributes. A health monitoring engine updates a health profile of the patient based on the correlated health attributes.

Saliva collection and testing system

A graphical user interface ('GUI') is generated on the display, the GUI has a graphical depiction that simulates a translucence level of an oral appliance. The graphical depiction of the translucence level is adjustable based on a user input. A value based on the user selected translucence level is sent to an external device for determination of manufacturing parameters for the oral appliance.

Systems and methods for customizing oral appliance appearance

An orthodontic appliance is constructed from shells shaped to receive teeth. The shells can be constructed from one or more polymer materials and stacked and also varyingly affixed to one another, which can include affixing only about the edge of each shell. The orthodontic appliance can be one of a series of similar appliances for incremental orthodontic modification of teeth.

Sterile lyophilized drug compositions and methods for treating ocular diseases or conditions

An orthodontic appliance shaped to receive teeth. The orthodontic appliance can be constructed from a laminate structure with an outer transparent layer and an inner translucent layer. The translucent layer can scatter light to decrease a relative degree or perceived gloss to the human eye, and hence provide a more natural appearance to the orthodontic appliance.

Growing community of inventors

Santa Clara, CA, United States of America

Loc Phan