University of Virginia Patent Foundation

Tau Therapeutics LLC

Lloyd S Gray

Doris M Haverstick

Timothy L MacDonald

Jaclyn R Patterson

William F McCalmont

Timothy L Macdonald

Gabor Szabo

Tiffany N Heady

John J Densmore

Andrew J Krouse

William F Mccalmont

Timothy Macdonald

Joel Linden

The present invention provides novel T type calcium channel inhibitors of formula (I), the use thereof in the treatment of a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, wherein Ris C-Calkyl, hydroxy, or C-Calkoxy; Z is NH, NCH, O, S, or CH; Y is NH, O, or CHwith the proviso that Y and Z are not the same; Ris H, halo, NH, C-Calkyl, hydroxy, or C-Calkoxy; m and n are independently selected from integers ranging from 1-5 with the proviso that m+n=an integer ranging from 2-9; and Ris H, halo, NH, C-Calkyl, hydroxy, or C-Calkoxy. 

T type calcium channel inhibitors

The present invention provides a method for imaging a disease or condition in a mammal which includes the steps of; administering a therapeutically effective amount of a cell cycle inhibitor to effectively stop proliferation of eukaryotic cells at a cell cycle checkpoint between the G1 and S phase, stopping administration of the cell cycle inhibitor for a period of time, administering a marker to the mammal and imaging the mammal.

Cancer diagnosis and imaging

The present invention provides novel T type calcium channel inhibitors of formula (I), the use thereof in the treatment of a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, wherein

The present invention is directed to compounds useful as cancer cell inhibitors, compositions containing such compounds and methods for inhibiting proliferation of electrically non-excitable cells.

Anticancer calcium channel blockers

The present invention provides methods for screening for voltage gated (VG)-selective inhibitors, novel VG-selective inhibitors, compositions containing the same, methods for inhibiting calcium entry into electrically non-excitable cells with said VG-selective inhibitors, methods for preventing proliferation of electrically non-excitable cells with said VG-selective inhibitors as well as methods of treating autoimmune diseases, preventing graft rejections, preventing apoptosis and treating cancer with the same.

Growing community of inventors

Louisa, VA, United States of America

Lloyd S Gray