Cobe Laboratories, Inc.

Cobe Cardiovascular, Inc.

Cobe Cardiovascular Operating Co., Inc.

Lloyd James Forrestal

Ben F Brian, Iii

Harold Fisher

Richard Alan Edrich

Yung-Ming Chen

The surface free energy of a polymer blend where a base polymer contains an additive having a different surface free energy than that of the base polymer can be controlled over a wide range of additive surface concentrations by appropriate choice of the mold surface free energy during fabrication. A high surface concentration of additive relative to a low bulk concentration can be achieved, leading to improved biocompatibility without loss of optical clarity.

Method for controlling surface concentration of a polymer additive

The biocompatibility of polymeric and metallic articles used in contact with blood can be substantially improved by coating the articles as described. The coating materials are triblock copolymers of the polylactone-polysiloxane-polylactone type. Optimum biocompatibility is provided by a coating of optimum surface concentration. Porous membranes can be coated as described, providing improved biocompatibility of blood oxygenators, hemodialyzers and the like.

Biocompatible coated article

Biocompatible anion exchange materials are provided comprising a support having a quaternary amine moiety and a polyethylene oxide (PEO) moiety having between about 10 and about 200 repeating units covalently bonded thereto, such that said quaternary amine and polyethylene oxide moieties are substantially homogeneously distributed on said support. These anion exchange materials are useful for removing negatively charged species such as heparin from blood and other body fluids without significant removal of platelets. Methods of making and using these materials are also provided.

Biocompatible anion exchange materials

A novel biocompatible anion exchange membrane is prepared by reacting the hydroxyl groups of a chromatographic support material with a polyester-cellulose solution containing glycidyl trimethyl ammonium chloride and bis glycidyl polyethylene oxide.

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Boulder, CO, United States of America

Lloyd James Forrestal