American Home Products Corporation

Scios Inc.

Lloyd G Chavez

Hsien-Jue Chu

William M Acree

Terri Wasmoen

Beverly Dale

Miles Yamanaka

Lucille W Chang

Mark Hall

Bonnie Wallace

Chengjin Huang

The present invention pertains to the prevention or lessening of disease in cats caused by Feline Immunodeficiency Virus (FIV). Prevention or lessening of disease is understood to mean the amelioration of any symptoms, including immune system disruptions, that result from FIV infection. The invention provides for a plasmid which encodes the FIV genome where said genome has had a portion of the gag gene, specifically the p10 (nucleocapsid) coding region, or a portion thereof, deleted. This deletion prevents the production of functional or whole p10 protein, which in turn, prevents the packaging of RNA into virions produced from transfection of this plasmid into an appropriate host cell, resulting in virions which do not contain RNA. Such virions will be described as &ldquo;empty&rdquo; virions. The invention also encompasses host cells transformed with the plasmid which produce the empty virions, and the empty virions themselves. In another embodiment, the invention encompasses vaccines that comprise one or more empty virions described above, with a pharmaceutically acceptable carrier or diluent and a pharmaceutically acceptable adjuvant. In yet another aspect, the invention provides methods for preventing or lessening disease caused by FIV, which is carried out by administering to a feline in need of such treatment the vaccines described above.

Plasmids comprising a genetically altered feline immunodeficiency virus genome

This invention provides a feline vaccine composition comprising an immunogenically active component having inactivated mammalian chlamydial cells or antigens derived there-from, in combination with an effective amount of an immunogenically suitable adjuvant; and a veterinary pharmaceutically acceptable carrier or diluent. The vaccine composition is useful to prevent chlamydia, e.g. C. psittaci, infections or diseases in felines, and may also be combined with other vaccine compositions or therapy. A process for producing C. psittaci suitable for use in the production of safe and effective chlamydia vaccines, and a method for preventing chlamydia infections or diseases in felines, are also provided.

Feline vaccine compositions and method for preventing chlamydia

The present invention provides recombinant raccoon poxviruses (RRPVs) useful in vaccines for the prophylaxis of disease caused by feline immunodeficiency virus (FIV). RRPVs according to the invention have at least one internal gene comprising a DNA sequence that encodes FIV gag protein (gag), FIV envelope protein (env), a polypeptide consisting of amino acids 1-735 of FIV env, or immunogenic fragments of any of the foregoing. The vaccines that comprise one or more of the FIV-expressing recombinant raccoon poxviruses described above may also comprise a pharmaceutically acceptable carrier or diluent and a pharmaceutically acceptable adjuvant. The invention also provides methods for preventing or lessening disease caused by FIV, which is carried out by administering to a feline in need of such treatment the vaccines described above.

Recombinant raccoon pox viruses and their use as an effective vaccine

This invention provides a recombinant raccoon poxvirus that express the envelope protein of Feline Immunodeficiency Virus. The recombinant viruses are useful as vaccines, either alone or in combination with carries and adjuvants.

The present invention relates to the development of an efficacious vaccine against Feline Infectious Peritonitis Virus (FIPV). The invention provides the tools for the synthesis and manipulation of the structural and non-structural proteins of FIPV. These proteins are able to elicit an immune response in cats against FIPV. The recombinant virus vectors which express the E1 or N proteins of the virus or the recombinant produced viral proteins themselves are able to elicit an immune response.

Recombinant structural and non-structural proteins of FIPV and method of

The present invention provides tools which are useful for the diagnosis of an animal's exposure to feline infectious peritonitis virus (FIPV) or susceptibility to FIPV. The diagnostic tools are composed of nucleic acid sequences which encode structural and nonstructural FIPV proteins and antibodies generated against FIPV proteins. The FIPV proteins may also be useful as subunit vaccines.

Feline infectious peritonitis virus diagnostic tools

This invention provides a recombinant raccoon poxvirus that expresses the nucleocapsid and transmembrane proteins of Feline Infectious Peritonitis Virus. The recombinant viruses are useful as vaccines, either alone or in combination with carriers and adjuvants.

A bovine vaccine composition comprising an immunogenically active component having inactivated bovine Trichomonas cells or antigens derived therefrom, in combination with an effective amount of an immunogenically suitable adjuvant; and a veterinary pharmaceutically acceptable carrier or dilent. The vaccine composition is useful to prevent Tritrichomonas (Trichomonas), e.g., T. foetus, infection in bovine, and may also be combined with other vaccine compositions or therapy. A method for preventing Trichomonas infection in bovine is also provided.

Bovine trichomonas vaccine compositions

This invention provides a recombinant raccoon poxvirus that expresses the nucleocapsid and transmembrane proteins of Feline Infectious Peritionitis Virus. The recombinant viruses are useful as vaccines, either alone or in combination with carriers and adjuvants.

Recombinant raccoon pox virus comprising the DNA encoding the

This invention provides a feline vaccine composition comprising an immunogenically active component having inactivated mammalian chlamydial cells or antigens derived therefrom, in combination with an effective amount of an immunogenically suitable adjuvant; and a veterinary pharmaceutically acceptable carrier or diluent. The vaccine composition is useful to prevent chlamydia, e.g. C. psittaci, infections or diseases in felines, and may also be combined with other vaccine compositions or therapy. A process for producing C. psittaci suitable for use in the production of safe and effective chlamydia vaccines, and a method for preventing chlamydia infections or diseases in felines, are also provided.

This invention provides a bovine vaccine composition comprising an immunogenically active component having inactivated bovine Trichomonas cells or antigens derived therefrom, in combination with an effective amount of an immunogenically suitable adjuvant; and a veterinary pharmaceutically acceptable carrier or diluent. The vaccine composition is useful to prevent Tritrichomonas (Trichomonas), e.g., T. foetusinfection in bovine, and may also be combined with other vaccine compositions or therapy. A method for preventing Trichomonas infection in bovine is also provided.

Growing community of inventors

Fort Dodge, IA, United States of America

Lloyd G Chavez