Qlt Inc.

Inex Pharmaceuticals Corporation

Ljiljana Kojic

Jeffery Jerome Wheeler

Pieter Rutter Cullis

Peter Scherrer

Patricia M Logan

Yuan-Peng Zhang

Gabriel Bela Kalmar

Kymberley L Sutton

Edward George Saravolac

Olga Ludkovski

Methods are provided to specifically modulate the activation of monocytes and/or macrophages. Administration of integrin linked kinase (ILK) blocking agents; compounds that otherwise prevent the binding of natural ILK ligands to ILK; or compounds that prevent expression of, or signaling through ILK exert an anti-inflammatory effect by inhibiting iNOS and COX-2 expression, at the level of transcription by suppressing the activation of NF-&#x3ba;B. The modulation of activation through ILK is used to regulate immune processes at targeted sites, for example to decrease undesirable inflammatory responses.

Integrin linked kinase modulation of monocyte activation

The present invention relates to lipid-based formulations for nucleic acid delivery to cells, methods for the preparation of such formulations and, in particular, to lipid encapsulated plasmids. The compositions are safe and practical for clinical use. In addition, the present invention provides methods for introducing nucleic acids into cells and for inhibiting tumor growth in cells using such lipid-nucleic acid formulations.

Methods for encapsulating nucleic acids in lipid bilayers

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Vancouver, Canada

Ljiljana Kojic