Shanghai Institute of Pharmaceutical Industry

Zhejiang Kangyu Pharmaceutical Co., Ltd.

Shanghai Forefront Pharma Co., Ltd.

Dsm IP Assets B.v.

Lizhi Zhao

Wei Zhang

Yi Ren

Ulla Letinois

Fuli Zhang

Kun Peng

Bin Rong

Meng Hu

Lingui Zhu

Mengya Ge

Xixiang Dai

Wei Li

Weifeng Cao

A method for preparing an L-erythrobiopterin compound is provided. The L-erythrobiopterin compound has a structure represented by formula (I), and is mainly prepared from a compound having a structure represented by formula (II) or (III) through dihydroxylation. The preparation method of the L-erythrobiopterin compound is high in production efficiency, low in cost, environmentally friendly, and suitable for industrial production.

Method for preparing L-erythrobiopterin compound

A new method of preparing memantine hydrochloride, comprising the following steps: reacting 1-bromo-3,5-dimethyl adamantane and urea/formic acid, with formic acid also acting as the solvent; hydrolyzing with aqueous inorganic acid; alkalifying, extracting and acidifying with hydrochloric acid; finally collecting target compound. The method uses inexpensive raw materials and is performed in homogeneous phase under mild conditions. It can achieve high yield and good product purity, and is suitable for macrochemistry. The purity of crude product is 99.0%, and reaches 99.98% after first recrystallization, yield: 69.5%, mp: 332 C (DSC).

Method of preparing memantine hydrochloride

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Shanghai, China

Lizhi Zhao