University of Michigan

Liyue Huang

Shaomeng Wang

Angelo Aguilar

Tianfeng Xu

Shilin Xu

Liu Liu

Chao-Yie Yang

Jeanne Stuckey

Denzil Bernard

Zhuo Chen

Dengyou Zhang

Ke Zheng

Canhui Zheng

Ke Zhang

The present disclosure provides compounds represented by Formula I and II: and the pharmaceutically acceptable salts and solvates thereof, wherein R, R, R, X, W, Y, and Z are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I and II for use to treat a condition or disorder responsive to LSD1 inhibition such as cancer. 

Pyrrolo[2,3-C]pyridines and related analogs as LSD-1 inhibitors

The present disclosure provides compounds represented by Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, R, R, R, R, R, R, R, R, R, X, Z, m, and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat a condition or disorder responsive to menin inhibition such as cancer. 

Piperidines as covalent menin inhibitors

The present disclosure provides compounds by Formula (I): (Formula (I)) and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R, R, R, A, G, X, and Y are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat a condition or disorder responsive to menin inhibition such as cancer. 

Piperidines as menin inhibitors

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Ann Arbor, MI, United States of America

Liyue Huang