Cspc Zhongqi Pharmaceutical Technology (shijiazhuang) Co., Ltd.

Cspc Zhongqi Pharmaceutical Technology (shijazhuang) Co., Ltd.

Liying Yang

Ying Peng

Xiaoliang Wang

Dongmin Shen

Jinghua Yang

Hanyu Yang

Wenmin Guo

Zhentao Liu

Yipu Feng

Rongduan Wang

Xiaolong Feng

Yuqing Gao

Jia Zheng

Jingguo Sun

Zhankun Yang

The present invention relates to a novel drug delivery and release system, i.e. Self-emulsifying Drug Delivery System (SEDDS), of butylphthalide, to a preparation process thereof, and to a use thereof in a pharmaceutical formulation. The drug delivery system comprises as essential ingredients 1% to 65% of butylphthalide and 10% to 65% of a emulsifying agent, together with various excipients as required depending on the desired dosage forms. The present invention significantly increases the contact area between butylphthalide and the mucous membrane of the gastrointestinal tract, and therefore improves the absorptivity of the drug.

Butylphthalide self-emulsifying drug delivery system, its preparation and method and application

The invention discloses the application of l-n-butylphthalide as formula (I) in preparing a medicine for preventing and treating dementia, in special Alzheimer's disease and vascular dementia. 

Application of L-n-butylphthalide in preventing and treating dementia

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Province, China

Liying Yang