Montage Technology (kunshan) Co., Ltd.

Suzhou Nggt Biotechnology Co., Ltd.

Lixin Jiang

Wenlin Xu

Jian Yin

Jinfu Chen

Hai Zhang

Bo Qu

Hui Yu

Qing Cao

Shengmei Wen

Provided are an optimized CPY4V2 gene and an application thereof. The gene relates to a polynucleotide for coding a CYP4V2 protein, and comprises a nucleotide sequence having 90% or over 90% of identity with a nucleotide sequence as shown in SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8 or SEQ ID NO: 9. Also provided is an expression vector comprising the gene. The expression vector can realize lasting and stable expression in retinal pigment epithelium of eyes, can effectively reduce the dosage and possible side effects of a gene therapy drug for treating BCD, and improves the therapeutic effect.

Optimized CYP4V2 gene and application thereof

A delay device and a delay control method are provided. The delay device includes at least one current-controlled delay group and at least one switch. The at least one current-controlled delay group is coupled to a transmission wire, each of the at least one current-controlled delay group includes at least one current-controlled delayer, and each of the at least one current-controlled delayer provides a delay according to a control voltage. The at least one switch is coupled between the at least one current-controlled delay group and the transmission wire, and each of the at least one switch is turned on or off according to a bit of an enable signal applied thereto. In the disclosure, the generated delay can be dynamically adjusted and cannot be affected by parasitic capacitance.

Delay device and delay control method

A delay device and a control method of transmission delay capable of performing temperature compensation are provided. The delay device includes a first current source, a second current source, a first resistor, and a delay adjustment circuit. The first current source is configured to provide a first current with a constant temperature coefficient. The second current source is connected to the first current source in parallel and is configured to provide a second current with a negative temperature coefficient. A first terminal of the first resistor is coupled to the first current source and the second current source. A second terminal of the first resistor is coupled to a reference ground terminal. The first resistor generates a control voltage at the first terminal of the first resistor according to the first current and the second current. The delay adjustment circuit is coupled to a transmission wire. The delay adjustment circuit determines a signal transmission delay of the transmission wire according to the control voltage.

Delay device and control method of transmission delay

The present disclosure provides a switching current source circuit and a method for quickly establishing a switching current source. The switching current source circuit includes a first and a second switching current source branches connected in parallel with one end of a load. When the switching enable signal is switched, due to the charge coupling of the first and second switching current source branches, the bias voltage respectively generates bounce in the same direction as and a direction opposite to the transition direction of the switching enable signal. The two bounces cancel each other to make the current source bias voltage recover quickly when a toggle event happens. The present disclosure accelerates the establishment of current through the coupling of charges, and reduces the decoupling capacitance at the same time, thereby reducing the circuit area and saving the costs.

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Suzhou, China

Lixin Jiang