Scimed Life Systems, Inc.

Lutonix Inc.

Boston Scientific Scimed, Inc.

Urotronic, Inc.

Neurotronic, Inc.

Covidien LP

Other

Ev3 Inc.

Tyco Healthcare Group LP

Boston Scientific Corporation

Lixiao Wang

Peter Barnett

John Jianhua Chen

Jianhua Chen

David Hendrickson

Dachuan Yang

Roger Noel Hastings

Yiqun Wang

Daniel James Horn

Paul J Buscemi

Kent David Harrison

Nao Pao Lee

Irina Nazarova

Donald F Palme, Ii

Elizabeth A Stejskal

Joel L Stanslaski

Charles L Euteneuer

Daniel M Lafontaine

Yongxing Zhang

Gary L Hendrickson

Jan Weber

Louis G Ellis

Jeffrey S Lindquist

Jianlu Ma

Paul James Miller

Victor Leo Schoenle

Joe Tatalovich

The Thomas Trinh Tran

Nie Tang

Thomas J Holman

Ronald A Sahatjian

Scott Raymond Smith

David John Sogard

Dennis W Wahr

Fernando DiCaprio

Sheng-Ping Zhong

Douglas Adelbert Devens, Jr

Albert C C Chin

Liguang Tang

Jeffrey Wang

Harrison Malinoff

Christopher M Barry

Scott R Naisbitt

The Thomas Tran

Linda J Vickerman

Huisun Wang

Richard S Kusleika

David A Ferrera

Maria Palasis

James J Barry

Timothy J Mickley

Richard J Olson

Daniel Keith Tomaschko

Ralph J Barry, Jr

Mark H Wyzgala

Xiaoling Zhao

Albert Chin

Richard Dunn

Leo M Klisch

Sew-Wah Tay

Brett Allyn Williams

Martin Chambers

George C Michaels

Eric B Hamilton

Nancy Haig

Joseph M Lyver

(Bruce) Yiqun Wang

Dan Ranum

Deborah A Frank

Ed Parsonage

Peggy Waltz

Keith Smythe

David Griswold

Khamla Vongphakdy

Daniel O Adams

Brian J Brown

Martin R Willard

Peter L Dayton

David J Blaeser

William Joseph Shaw

Jon St Germain

Steven E Walak

Steven Paul Mertens

Michael J Urick

Mark T Ungs

Joel R Munsinger

Jason Todd Lenz

Kenneth M Merdan

Robert Burgmeier

Eric B Stenzel

Ron A Drake

Mona N Dahdah

Rich Kusleika

Lance A Monroe

Daniel J Vreeman

Ismail Guler

Tom J Hiblar

Dale F Schmaltz

Thomas J Hiblar

Steve Zaver

Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

Drug-coated balloon catheters for body lumens

Embodiments of the present invention provide a method of treating a stricture in a nonvascular body lumen such as urethral strictures, benign prostatic hyperplasia (BPH) strictures, ureteral strictures, esophageal strictures, sinus strictures, and biliary tract strictures. Embodiments of the present invention provide a method for treating at least one of benign prostatic hyperplasia (BPH), prostate cancer, asthma, and chronic obstructive pulmonary disease (COPD). The method can include delivering, for example, via drug coated balloon catheters, anti-inflammatory and anti-proliferative drugs (e.g., rapamycin, paclitaxel, and their analogues) and one or more additives.

Drug coated balloon catheters for nonvascular strictures

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspension of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.

Chemical ablation and method of treatment for various diseases

Embodiments of the present invention are directed to the treatment of hypertension, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pains, asthma, pulmonary arterial hypertension, and chronic obstructive pulmonary disease by delivering of an effective amount of formulations at desired temperature to target tissue. The formulations include gases, vapors, liquids, solutions, emulsions and suspensions of one or more ingredients. The temperature may enhance safety and efficacy of the formulations for the treatments. The amounts of the formulation and/or energy are effective to injury or damage the tissues to have a benefit of symptom relive.

Chemical ablation formulations and methods of treatments for various diseases

Balloon catheters for body lumens

Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.

A balloon catheter for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen; the balloon catheter comprising: An elongated balloon; a coating layer overlying an exterior surface of the balloon wherein the coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent; and a length-control mechanism () which stretches and elongates the balloon during deflation, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

Balloon catheters, methods for preparing balloon catheters, and uses of balloon catheters are disclosed. The balloon catheter includes an elongate member, an expandable balloon, and a coating layer overlying an exterior surface of the expandable balloon. The coating layer includes a total drug load of a hydrophobic therapeutic agent and a combination of additives including a first additive and a second additive. The hydrophobic therapeutic agent is paclitaxel, rapamycin, or paclitaxel and rapamycin. The first additive is a surfactant. The second additive is a chemical compound having one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide, or ester groups.

Drug releasing coatings for balloon catheters

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Henderson, NV, United States of America

Lixiao Wang