Institute of Microbiology, Guangdong Academy of Sciences (guangdong Detection Center of Microbiology)

Guangdong Institute of Microbiology (guangdong Detection Center of Microbiology)

Liwei Xie

Mulan Han

Guohuan Xu

Bingdong Liu

Zhihong Liu

Xiaohan Pan

An application of a skeletal muscle secreted factor Thbs4 in a preparation of a drug for improving systemic glucose and lipid metabolism is provided. According to the present invention, it is found through experiments that Thbs4 increases a body's metabolic rate by activating a beige-like change of white adipose, relieves the metabolic disorder caused by high-fat diet, and reveals its application value in the treatment of the metabolic disorder.

Application of skeletal muscle secreted factor THBS4 in preparation of drug for improving systemic glucose and lipid metabolism

A high-throughput virtual drug screening system based on molecular fingerprints and deep learning, includes a deep-learning model online-modeling subsystem and an online virtual-screening subsystem. The system combines the molecular fingerprints and a deep neural network method to construct a high-throughput virtual drug screening system. The system includes built-in structural-diversity screening libraries and realizes the online automatic construction of deep learning models and virtual screening. The system helps researchers in the drug discovery industry such as medicinal chemistry to conduct rapid screening through their desired targets to obtain potential active compounds and accelerate drug discovery.

High-throughput virtual drug screening system based on molecular fingerprints and deep learning

Growing community of inventors

Guangzhou, China

Liwei Xie