Manus Bio Inc.

Givaudan S.a.

Manus Biosynthesis, Inc.

Liwei Li

Ajikumar Parayil Kumaran

Christopher Pirie

Souvik Ghosh

Chin Giaw Lim

Anthony Qualley

Jason Eric Donald

Ryan Philippe

Ryan Lim

Geoff Marshall-Hill

Martin Preininger

Krishna Patel

Swati Gupta

Huey-Ming Mak

Srishti Tibrewala

The present invention relates to methods for producing oxygenated terpenoids. Polynucleotides, derivative enzymes, and host cells for use in such methods are also provided.

Methods for production of oxygenated terpenes

The invention provides methods for making steviol glycosides, including RebM and glycosylation products that are minor products inleaves, and provides enzymes, encoding polynucleotides, and host cells for use in these methods. The invention provides engineered enzymes and engineered host cells for producing steviol glycosylation products, such as RebM, at high purity and/or yield. The invention further provides methods of making products containing steviol glycosides, such as RebM, including food products, beverages, oral care products, sweeteners, and flavoring products.

Uridine diphosphate-dependent glycosyltransferase circular permutants

The present disclosure relates to methods for producing oxygenated terpenoids, and preparation of compositions and formulations thereof. Polynucleotides, derivative enzymes, and host cells for use in such methods are also provided.

The present invention relates to the production of chemical species in bacterial host cells. Particularly, the present invention provides for the production of chemical species in() host cells that functionally express engineered P450 enzymes.

Increasing productivity ofhost cells that functionally express P450 enzymes

The invention provides methods for making steviol glycosides, including RebM and glycosylation products that are minor products in stevia leaves, and provides enzymes, encoding polynucleotides, and host cells for use in these methods. The invention provides engineered enzymes and engineered host cells for producing steviol glycosylation products, such as RebM, at high purity and/or yield. The invention further provides methods of making products containing steviol glycosides, such as RebM, including food products, beverages, oral care products, sweeteners, and flavoring products.

Microbial production of steviol glycosides

Growing community of inventors

Cambridge, MA, United States of America

Liwei Li