Zach System S.p.a.

Wyeth

Industrie Chimiche Caffaro S.p.a.

Zach Systems S.p.a.

Zach System

Chiesi Farmaceutici S.p.a.

Zambon S.p.a.

Zetacube S.r.l.

F.i.s. Fabbrica Italiana Sintetici S.p.a.

Livius Cotarca

Massimo Verzini

Paolo Maragni

Giorgio Soriato

Johnny Foletto

Raffaella Volpicelli

Roberto Giovanetti

Roberto Brescello

Ivan Michieletto

Andrea Nicoli

Massimiliano Forcato

Franco Massaccesi

Vincenzo Cannata

Pietro Allegrini

Alberto Guidi

Nicola Catozzi

Paolo Andreella

Elisa Melotto

Ilaria Munari

Alfonso Melloni

Mauro Andretto

Giuseppe Barreca

Paolo Maggioni

Alfonso Nardelli

Angelo Restelli

Yvon Derrien

Fabio Bassan

Patricia Poirier

Francesco Tasinato

Anna Smaniotto

Daniele Urbani

Antonio Nardi

Marco Demo

Corrado Colli

Franco Pellacini

Mauro Napoletano

Dario Braga

Francisco Marquillas Olondriz

Gabriele Morazzoni

Aldo Belli

Kadum A Ali

Elio Ullucci

Pietro Delogu

Stefano Sguassero

Stefano Alini

Tony Pintus

Franco Ghelfi

Sebastien Meunier

Carl E Longfellow

Stefano Poli

Shridhar G Gangolli

Roberto Bianchini

Malama K Chibwe

Pierrick Morice

Maurizio Polentarutti

Giorgio Bais

Jasper Rikkert Plaisier

Fabio Belluzzo

Alessandro Di Maria

Laurence Graindorge

Vincenzo Frega

Filippo Chiarello

Gianmauro Orru'

Jean-Claude Kizirian

Elisenda Trepat Guixer

Enrico Pace

Fabrizio Roncaglia

Mauro Maffini

Paolo Fornasari

Franco Brazzarola

Dario Università Di Bologna Braga

Sébastien Meunier

Maurizio Benaglia

The present invention relates to a process for the preparation of 17-substituted steroids and, more particularly, to an improved method of preparing micro size abiraterone or derivatives thereof in high yield and purity by means of a spherical agglomeration process.

Process for producing a solid form of abiraterone acetate

The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II): wherein G is &#x2014;CN or &#x2014;COOR in which R is a C-Cstraight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, RO&#x2014; and RS&#x2014; wherein Ris C1-C4 straight or branched alkyl chain. 

Cyclopropanation of substituted phenylacetonitriles or phenyl acetates

A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride or another pharmaceutically acceptable anionic counterion.

Process for preparing Cinacalcet hydrochloride

A method of detecting polymorphs using X-ray produced by a synchrotron source is described. In particular, the method allows to detect particular polymorphs present in small amounts in mixtures of polymorphic compounds present in a prevailing amount. The method offers a powerful resolution of mixtures of polymorph and finds application particularly in the pharmaceutical field.

Method of detecting polymorphs using synchrotron radiation

The present invention relates to a chiral oxamide of formula (I) useful as an intermediate in the preparation of dorzolamide, and to the preparation thereof. The invention also relates to the preparation of dorzolamide, to the hydrochloride salt thereof, and to the active ingredient contained in a drug useful in the treatment of glaucoma, by means of the intermediate of formula (I). 

Process for preparing enantiomerically enriched oxamides

The present invention relates to a process for preparing gabapentin and, more particularly, it relates to a process for the direct extraction of gabapentin from an aqueous solution derived from the Hofmann rearrangement of 1,1-cyclohexanediacetic acid monoamide.

Process for preparing gabapentin

The present invention relates to a process for the preparation of 17-substituted steroids and, more particularly, to an improved method of synthesizing abiraterone or derivatives thereof in high yield and purity by means of a key 3-formate intermediate.

Process for preparing 17-substituted steroids

The present invention relates to a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof:   wherein R is as defined above and G is &#x2014;CN or &#x2014;COORwherein Ris a C-Cstraight or branched alkyl chain.

Process for the preparation of derivatives of 1-(2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid

The present invention relates to a process for preparing a ketosulfone derivative and, more particularly, to an improved method for synthesizing 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]ethanone by means of Pd-catalized alpha arylation process of a heteroaromatic ketone derivative.

Process for preparing a ketosulfone derivative

The present invention relates to a process for preparing Nebivolol and, more in particular, to a fractional distillation method of a mixture of stereoisomers of formula intermediates useful in the preparation of nebivolol.

Process for preparing nebivolol

The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.

Process for preparing Bosentan monohydrate and it's intermediates

The present invention relates to a stereoselective reduction procedure to obtain, by means of catalytic asymmetric hydrogenation by hydrogen transfer, a compound of formula (I) in which X is S or SOand Ris hydrogen or an SONHgroup, from the corresponding ketone precursor, said compound of formula (I) being useful as an intermediate in the preparation of dorzolamide or of the hydrochloride salt thereof. 

Asymmetric reduction process

The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved method of debenzylation of a compound of formula (II) useful for preparing nebivolol endowed with high purity. 

Process for preparing Nebivolol

The present invention relates to a process for the preparation of olopatadine and, more particularly, to an improved method of synthesizing olopatadine which comprises reacting a dibenz[b,e]oxepin-11-one derivative of formula (III) and a suitable reagent under Witting condition, and to the intermediate 11-[(Z)-3-(dimethylamino)-propylidene]-6-11-dihydrodibenz[b,e]-oxepin-2-acet-amide p-toluensulfonate salt. 

Process for preparing olopatadine and/or a pharmaceutically acceptable salt thereof

A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula hydrochloride salt of formula (I) i.e. Cinacalcet.HCl and its intermediate of formula (IX) 

Process for preparing cinacalcet

Growing community of inventors

Cervignano del Friuli, Italy

Livius Cotarca