Chinese Academy of Sciences

Yunnan University

Liumeng Yang

Yongtang Zheng

Hongbin Zhang

Ruirui Wang

Yanping He

Chengrun Tang

Jian Li

Yu Chen Zhou

Jing Li

Hong Tao Liu

Hualiang Jiang

Kaixian Chen

Xin Xie

Ying Chen

Jikai Liu

Yu Zhou

Hong Liu

Haonan Zhang

Panfeng Peng

Weilie Xiao

Wei Ding

Jiangyuan Wang

Ruomei Rui

Yumeng Wu

Yiming Li

Jianwen Tan

Zejun Dong

Xiangdong Qin

Jianxin Pu

Handong Sun

Jingping Liu

Ya Zhu

Ronghua Luo

Yufang Zhang

Beili Wu

Disclosed is a pyrimidinone-containing compound represented by formula I, a preparation method thereof, a pharmaceutical composition, and an application thereof. The pyrimidinone-containing compound of the present disclosure can be used as HIV-1 inhibitor and can be also used in the treatment of human immunodeficiency virus infection. 

Pyrimidinone-containing compound, preparation method thereof, pharmaceutical composition and application thereof

Disclosed is a DACOs-type NNRTIs amino acid ester derivative, a preparation method thereof, a pharmaceutical composition, and an application thereof. The structure of the DACOs-type NNRTIs amino acid ester derivative is represented by formula (I). The DACOs-type NNRTIs amino acid ester derivative represented by formula (I) can be used as HIV-1 inhibitors and for the preparation of a drug for treating and/or preventing immunodeficiency viruses. 

DACOS type NNRTIS amino acid ester derivative, preparation method thereof, pharmaceutical composition, and application thereof

Provided are 1-(3-aminopropyl) substituted cyclic amine compounds as represented by frmula (I), pharmaceutically acceptable salts, enantiomers, diastereoisomers, racemates and mixtures thereof, and a method of synthesizing said 1-(3-aminopropyl) substituted cyclic amine compounds by using aromatic heterocyclic formaldehyde as raw material. Said compounds can be used as CCR 5 antagonist for the treatment of HIV infection. 

1-(3-aminopropyl) substituted cyclic amine compounds, preparation method therefor, and pharmaceutical compositions and uses thereof

Nitrogen-containing biphenyl compounds as represented by formula (I), pharmaceutically acceptable salts or derivatives thereof, pharmaceutical compositions, and preparation methods therefore, and anti-HIV-1 use of the compound. Each substituent group in formula (I) is as defined in the description. 

Nitrogen-containing biphenyl compounds, pharmaceutical compositions of same, preparation methods and anti-HIV-1 uses thereof

The present invention relates to concentricolide and its derivatives, a method for the preparation of the compound and its derivatives, a pharmaceutical composition containing concentricolide and its derivatives, and use of the compound and its derivatives for the treatment and prevention of infection caused by human immunodeficiency virus (HIV).

Concentricolide and its derivatives, process for preparing them, pharmaceutical composition comprising the same and its use

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Kunming, China

Liumeng Yang