Edwards Lifesciences Corporation

Lisong Ai

J Brent Ratz

Louis A Campbell

Son V Nguyen

Alexander H Cooper

August R Yambao

Kevin K Dang

Harvey H Chen

Grace Myong Kim

Matthew A Peterson

Hieu Minh Luong

Julio Cesar Sanchez

Alyssa E Kornswiet

Jyoti B Rao

Diana Marie Edwards

Juliet Laura Schwartz

Meena Francis

Edward Romero

Stephen W Tang

Devin D Nguyen

Wendy Vo Pham

Devine D Nguyen

Diana Marie George

A hybrid heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The hybrid heart valve includes a substantially non-expandable, non-compressible prosthetic valve member having a peripheral sealing ring and an expandable stent frame projecting from an inflow end, thereby enabling attachment to the annulus without sutures. The stent frame may be plastically-expandable and may have a thin fabric layer covering its entirety as well as secondary sealing structures around its periphery to prevent paravalvular leaking. Other sealing solutions include interactive steps at the time of valve implant to establish seals around the stent and especially between the stent and the sealing ring of the valve member.

Heart valve sealing assemblies

A mitral valve prosthesis includes an hourglass shaped inner frame and a bulbous outer frame. A valve body having a plurality of leaflets is positioned within an interior region of the inner frame. The leaflets are shaped to substantially conform to an interior surface of the inner frame when the leaflets are in an open position. As a result, the gap between the leaflets and the inner frame is decreased, thereby reducing the likelihood of thrombus formation. Ventricular anchors are preferably provided along a distal end of the inner frame. The anchors extend proximally for placement behind native mitral valve leaflets. A fabric skirt may extend along an inner or outer surface of the outer frame. In preferred embodiments, the fabric skirt extends distally beyond a distal end of the outer frame and is adapted for forming a seal along the mitral valve annulus.

Prosthetic mitral valve with improved anchors and seal

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Irvine, CA, United States of America

Lisong Ai