Massachusetts Institute of Technology

Liselotte Kaiser

Shuguang Zhang

Andreas Mershin

Brian Cook

Yael Gregory Maguire

Dai Ohnishi

Yoshikatsu Miura

Manu Prakash

David Kong

Daisuke Niwa

Atsushi Tazuke

Johanna F Bikker

Johanna F Graveland-Bikker

The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor&#x2014;the olfactory receptor&#x2014;on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor&#x2014;the olfactory receptor&#x2014;immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

Bio-sensing nanodevice

The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

Multiplexed olfactory receptor-based microsurface plasmon polariton detector

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Stockholm, Sweden

Liselotte Kaiser