Abbott Laboratories Corporation

Abbott Cardiovascular Systems, Inc.

Lisa Weldon

Stephen D Pacetti

Ellen T Roche

Greg Hyde

Maithili Shrivastava

Ketan P Muni

Anton G Clifford

David Lowe

Gordon S Stewart

Victoria May Gong

Erik Eli

Jeff Pappas

Howard Huang

Eugene Young

Kevin Kang

Chandana Bellam

A method of manufacturing a stent includes applying a coating to the stent and changing an amount of the coating being applied to the stent by modifying the diameter of the stent.

Methods of modifying stent coating thicknesses

The present invention relates to methods of applying a drug&#x2014;polymer coating layer onto an implantable medical device or another substrate, and the use of a choice of solvents to adjust the release of the drug from the coating. The drug to polymer ratio is about 1:1 to 1:3 on a mass basis. The polymer and the drug are hydrophobic.

Methods of application of coatings composed of hydrophobic, high glass transition polymers with tunable drug release rates

The present invention provides a method of manufacturing a stent having a coating, comprising providing a tubular stent having a lumenal side and an ablumenal side; applying a coating composition to the stents such that the coating composition contacts the lumenal and ablumenal sides of the stent; and modifying the diameter of the stent from a first diameter to a second diameter during the process of applying the coating composition.

Methods of modifying ablumenal/lumenal stent coating thicknesses

Endoprosthesis, such as a stent, includes at least one annular element defined by a first set of strut members interconnected to define apices proximate opposite sides of the annular element. The annular element further includes a foot extension extending between at least one pair of circumferentially-adjacent strut members. The foot extension has first and second foot portions extending circumferentially from corresponding ends of the circumferentially-adjacent strut members, and are contoured to provide at least two areas of flexure. The first and second foot portions are joined at a toe portion of the foot extension, and define a circumferentially-directed apex between the pair of circumferentially-adjacent strut members. Preferably, at least one or more additional annular elements, each defined by interconnected strut members, are provided. The annular elements are generally expandable between a delivery configuration and a deployed configuration. The annular elements are longitudinally aligned and connected at connection locations. Preferably, each connection location includes a foot extension, such as by an overlapping pattern between the longitudinally-adjacent annular elements or by a connector extending therebetween.

Endoprosthesis having foot extensions

An apparatus for measuring particles generated from a medical device during a simulated clinical application includes a platform configured for retaining at least one medical device and at least one simulated body lumen tubing. The platform includes the following: a medical device receptacle dimensioned to retain the at least one medical device; a pretest receptacle dimensioned to retain pretest tubing; and a test receptacle dimensioned to retain test tubing, said test receptacle having at least one substantially straight portion configured for straightening said test tubing when disposed therein and at least one tortuous portion configured for bending said test tubing into a tortuous pathway when disposed therein. Additionally, the platform includes a junction that interconnects the medical device receptacle, pretest receptacle, and test receptacle.

Apparatus and system for measuring of particles generated from medical devices or instruments utilized during simulated clinical applications

An apparatus for measuring particles generated from a medical device includes a platform configured for retaining at least one medical device and at least one simulated body lumen tubing. The platform includes: a medical device receptacle dimensioned to retain a medical device; a pretest receptacle dimensioned to retain pretest tubing; and a test receptacle dimensioned to retain test tubing. The apparatus can be used for measuring particles generated from a medical device during a simulated clinical application by the following: introducing the medical device into the test tubing; causing fluid to flow through the pretest tubing, past the medical device, and through the test tubing; and counting the particles in the fluid downstream from the medical device.

Method for measuring of particles generated from medical devices or instruments utilized during simulated clinical applications

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Mountain View, CA, United States of America

Lisa Weldon