3-d Matrix, Ltd.

Vicus Therapeutics, LLC

Lisa Spirio

Eun Seok Gil

Satoru Kobayashi

Zen Chu

John Maki

Methods and materials for mitigating biological tissue adhesion are described herein. One method for mitigating adhesion to a biological tissue includes administering an effective amount of a self-assembling peptide solution to the biological tissue, wherein the self-assembling peptide is between about 7 amino acids and 32 amino acids in length and the self-assembling peptide solution forms a hydrogel under physiological conditions.

Preventing biological tissue adhesion

Combination compositions comprising self-assembling peptides and payload agents, and methods of making and using such compositions, are described.

Combination compositions

In various aspects the present inventions provide compositions and methods for treatment of cardiac conditions. In various embodiments, the present inventions provide methods for treating a cardiac condition comprising the step of administering in a therapeutically effective amount the substantially cell free solution of an amphiphilic self-assembling peptide to a site of cardiac tissue that has been injured due to one or more of atrial fibrillation, acute myocardial infarction; valve disease, pericardial disease, congenital heart disease, congestive heart failure, and embolism.

Growing community of inventors

Lexington, MA, United States of America

Lisa Spirio