The University of Texas System

Baylor College of Medicine

Lisa N Kinch

Beth Levine

Olivier Lichtarge

Angela D Wilkins

Sanae Shoji-Kawata

Nick V Grishin

Beth C Levine

An autophagy-inducing compound comprises an autophagy-inducing peptide comprising Beclin 1 peptides immediately N- and C-terminally flanked by moieties Rand R, respectively, wherein up to six of said peptide residues may be substituted, Rand Rdo not naturally flank the Beclin 1 residues, and F270 and F274 are optionally substituted and optionally linked. The compounds may be used to induce autophagy.

Autophagy-inducing peptide analogs

An autophagy-inducing compound comprises an autophagy-inducing peptide comprising Beclin 1 residues 269-279 immediately N- and C-terminally flanked by moieties Rand R, respectively, wherein up to six of said residues may be substituted, Rand Rdo not naturally flank the Belclin 1 residues, and F270 and F274 are optionally substituted and optionally linked. The compounds may be used to induce autophagy.

Growing community of inventors

Dallas, TX, United States of America

Lisa N Kinch