Pharmacia & Upjohn Company

Pfizer Corporation

Pah P&u LLC

Lisa Marie Thomasco

Robert C Gadwood

Michael R Barbachyn

Arthur Glenn Romero

Peter Laurence Toogood

Dennis Joseph McNamara

John R Palmer

Alexander Ross Hurd

Debra Ann Sherry

J Craig Ruble

Paul Joseph Dobrowolski

Gordon L Bundy

Donna Lee Romero

Paul A Aristoff

Richard Charles Thomas

David John Anderson

Paul D Johnson

Toni-Jo Poel

Vara Prasad Venkata Nagendra Josyula

Frederick Earl Boyer

Ji-Young Kim

Gordan L Bundy

Gary E Martin

Allison Laura Choy

Gary L Cleek

Michael Robert Barbachyn

Dennis Joseph Mcnamara

John Raymond Palmer

The present invention is directed to tricyclic tetrahydroquinoline compounds of formula I, and pharmaceutically acceptable salts thereof wherein the variables R, R, R, R, R, Rand X are as described herein and to pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.

Tricyclic tetrahydroquinoline antibacterial agents

The invention includes tetrahydroquinoline and related compounds of formula I and pharmaceutical compositions thereof, that exhibit useful antibacterial activity again a wide range of human and veterinary pathogens 

The present invention relates to acyloxymethylcarbamate oxazolidinones. The compounds of the present invention have potent activity with excellent oral bioavailability against Gram-positive and Gram-negative bacteria.

Acyloxymethylcarbamate prodrugs of oxazolidinones

The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens 

The present invention provides oxazolidinones having a benzannelated 6- or 7-membered heterocycle as antibacterial agents.

Oxazolidinones having a benzannulated 6-  or 7-membered heterocycle

Disclosed are novel compounds that are useful and effective as photoaffinity probes and methods of using oxazolidinone photoaffinity probes.

Oxazolidinone photoaffinity probes

The present invention provides compounds of the formula:compositions comprising such compounds, and methods for using the same.

The present invention provides thiadiazolyl and oxadiazolyl phenyl oxzolidinone compounds of formula I ##STR1## wherein Q is thiadiazolyl or oxadiazolyl; wherein X.sup.1 and X.sup.2 are independently hydrogen, fluorine or chlorine; and

Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents

Bicyclic oxazine and thiazine oxazolidinone antibacterials

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Kalamazoo, MI, United States of America

Lisa Marie Thomasco