Codexis, Inc.

Calysta, Inc.

Lisa Marie Newman

Gjalt W Huisman

S Christopher Davis

Emily Mundorff

John M Gruber

Stephane J Jenne

John H Grate

Louis Clark

Richard John Fox

Dipnath Baidyaroy

Xiyun Zhang

Charlene Ching

James Joseph LaLonde

Roger Arthur Sheldon

Vesna Gavrilovic

Lorraine Joan Giver

Jian Ding

Jie Yang

Behnaz Behrouzian

Sally Rhiannon Postlethwaite

Attila Andor

David R Gray

Steven K Ma

Li A Wang

Jun Zhu

Jack S Liang

Benjamin Mijts

Michael D Clay

Anke Krebber

Jagadeesh Mavinahalli

Sheela Muley

John D Munger, Jr

Jeffrey Colbeck

Anke Kebber

Joshua A Silverman

Vesna Mitchell

Luan Thanh Nguyen

Drew D Regitsky

James LaLonde

Howard Lam Ho Fong

Emily Mundorrf

The present disclosure provides compositions and methods for using recombinant C1 metabolizing microorganisms capable of metabolizing sulfur containing compounds and other contaminants to biologically convert sour or acidic natural gas into high-value molecules, and to allow recovery of stranded oil.

Compositions and methods for recovery of stranded gas and oil

The invention relates to recombinantly produced &#x3b2;-glucosidase variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant &#x3b2;-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target &#x3b2;-glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue.

Beta-glucosidase variants

The present invention provides compositions and methods for the expression of recombinant &#x3b2;-glucosidase variants, as well as their use in the production of fermentable sugars from cellulosic biomass.

Polynucleotides encoding beta-glucosidase variants

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

Ketoreductases and uses thereof

&#x3b2;-glucosidase variants

The invention relates to recombinantly produced &#x3b2;-Glucosidase Variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant &#x3b2;-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target &#x3b2;-glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue.

&#x3b2;-Glucosidase variants

The invention provides variants of theCglT beta-glucosidase that have improve beta-glucosidase activity compared to the wild type enzyme. The invention also provides polynucleotides that encode the variants, as well as methods of producing the variants, enzyme compositions comprising the variants, and methods for using the variants in industrial applications.

Beta-glucosidase variant enzymes and related polynucleotides

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The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.

Polynucleotides encoding ketoreductases for producing stereoisomerically pure statins and synthetic intermediates therefor

The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M', and Rare as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds

The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.

Halohydrin dehalogenases and related polynucleotides

Engineered ketoreductases and methods for producing stereoisomerically pure statins

The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M', and Rare as described herein.

Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds

Growing community of inventors

San Jose, CA, United States of America

Lisa Marie Newman